Tbio UBXN4 UBX domain-containing protein 4

Protein Summary

Description

Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q92575
• A8K9W4
• Q4ZG56
• Q8IYM5

Gene Name

• UBXN4

Ensembl ID

• ENST00000272638
• ENSP00000272638
• ENSG00000144224

Symbol

• KIAA0242
• UBXD2
• UBXDC1
• UBXD2
• UBXDC1
• erasin

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
transcription factor binding site profile	0.85
microRNA	0.77
kinase perturbation	0.76
cell type or tissue	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.08   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.08   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0