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Tbio
UBXN4
UBX domain-containing protein 4

Protein Summary
Description
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272638
  • ENSP00000272638
  • ENSG00000144224

Symbol
  • KIAA0242
  • UBXD2
  • UBXDC1
  • UBXD2
  • UBXDC1
  • erasin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor binding site profile
0.85
microRNA
0.77
kinase perturbation
0.76
cell type or tissue
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
BCL11A
Tbio
Family:  TF
Novelty:  0.00456607
p_int:  0.999999994
p_ni:  5e-9
Score:  0.817
Data Source:  BioPlex,STRINGDB
TMEM134
Tdark
Novelty:  0.42629221
p_int:  0.999999988
p_ni:  1.1e-8
Data Source:  BioPlex
IP6K1
Tbio
Family:  Kinase
Novelty:  0.03418032
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.679
Data Source:  BioPlex,STRINGDB
UBE4A
Tbio
Novelty:  0.02576018
p_int:  0.999999911
p_ni:  7.7e-8
p_wrong:  1.2e-8
Score:  0.891
Data Source:  BioPlex,STRINGDB
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.999996893
p_ni:  0.000001071
p_wrong:  0.000002037
Data Source:  BioPlex
VPS13C
Tbio
Novelty:  0.05207291
p_int:  0.99988769
p_ni:  0.00011231
Score:  0.332
Data Source:  BioPlex,STRINGDB
VPS13A
Tbio
Novelty:  0.00581335
p_int:  0.998771333
p_ni:  0.001228667
Score:  0.332
Data Source:  BioPlex,STRINGDB
DPP8
Tchem
Family:  Enzyme
Novelty:  0.00678793
p_int:  0.972086292
p_ni:  0.023574997
p_wrong:  0.004338711
Score:  0.196
Data Source:  BioPlex,STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.85928973
p_ni:  0.000065383
p_wrong:  0.140644887
Score:  0.791
Data Source:  BioPlex,STRINGDB
UBXN6
Tbio
Novelty:  0.08383376
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
24
9
19
8.1
97.4
1,5 anhydroglucitol measurement
1
1
0
16.9
94.1
leukocyte count
4
4
5
91.1
neutrophil count
3
2
3
80.2
high density lipoprotein cholesterol measurement
5
3
5
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
19
8.1
97.4
1,5 anhydroglucitol measurement
0
16.9
94.1
leukocyte count
5
91.1
neutrophil count
3
80.2
high density lipoprotein cholesterol measurement
5
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UBX domain protein 4
VGNC:2901
459632
Macaque
UBX domain protein 4
712091
Mouse
MGI:1915062
67812
Rat
RGD:1307451
304766
Dog
UBX domain protein 4
VGNC:48100
476130
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UBX domain protein 4
Macaque
UBX domain protein 4
Mouse
Rat
Dog
UBX domain protein 4
Publication Statistics
PubMed Score 7.08
PubMed score by year
PubTator Score 2.71
PubTator score by year
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Related Publications
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PMID
Year
Title