Tbio UBXN11 UBX domain-containing protein 11

Protein Summary

Description

May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity). This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q5T124
• D3DPK6
• Q5T117
• Q5T120
• Q5T125
• Q5T126
• Q5T129
• Q5T131
• Q5T133
• Q63HM6
• Q71RB3
• Q8IY27
• Q8N1L6
• Q8N9M4
• Q8NA18
• Q8NFE3
• Q8NFE4
• Q8NFE6

Gene Name

• UBXN11

Ensembl ID

• ENST00000314675
• ENSP00000324721
• ENSG00000158062
• ENST00000357089
• ENSP00000349601
• ENST00000374217
• ENSP00000363334
• ENST00000374221
• ENSP00000363338
• ENST00000374222
• ENSP00000363339

Symbol

• SOC
• UBXD5
• SOC
• SOCI
• COA-1
• UBXD5
• PP2243

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.9
transcription factor	0.72
tissue	0.65
cellular component	0.57
tissue sample	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.3   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.3   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0