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Tbio
UBTF
Nucleolar transcription factor 1

Protein Summary
Description
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302904
  • ENSP00000302640
  • ENSG00000108312
  • ENST00000343638
  • ENSP00000345297
  • ENST00000393606
  • ENSP00000377231
  • ENST00000436088
  • ENSP00000390669
  • ENST00000526094
  • ENSP00000432925
  • ENST00000529383
  • ENSP00000435708
  • ENST00000533177
  • ENSP00000437180

Symbol
  • UBF
  • UBF1
  • UBF
  • UBF1
  • UBF2
  • UBF-1
  • CONDBA
  • NOR-90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.98
disease perturbation
0.93
protein complex
0.89
hub protein
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.81   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.81   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (190)
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999999963
p_ni:  3.7e-8
Score:  0.162
Data Source:  BioPlex,STRINGDB
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999999897
p_ni:  1.03e-7
Score:  0.168
Data Source:  BioPlex,STRINGDB
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.999999877
p_ni:  1.23e-7
Data Source:  BioPlex
EDA
Tbio
Novelty:  0.00352464
p_int:  0.999986148
p_ni:  0.000013851
Data Source:  BioPlex
NOG
Tbio
Novelty:  0.0010373
p_int:  0.999898186
p_ni:  0.000101814
Data Source:  BioPlex
PES1
Tbio
Novelty:  0.07162845
p_int:  0.999857189
p_ni:  0.000142811
Score:  0.376
Data Source:  BioPlex,STRINGDB
MDK
Tchem
Novelty:  0.00145301
p_int:  0.999406368
p_ni:  0.000593632
Data Source:  BioPlex
CPNE7
Tbio
Novelty:  0.0748235
p_int:  0.998518871
p_ni:  0.001481129
Score:  0.186
Data Source:  BioPlex,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.997368219
p_ni:  0.002631781
Data Source:  BioPlex
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.996478003
p_ni:  0.003521997
Score:  0.304
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Epigenetic regulation of gene expression (R-HSA-212165)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Reactome
RNA Polymerase I Promoter Clearance
Name
Explore in Pharos
Explore in Source
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
RNA Polymerase I Promoter Clearance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
6
9
98.8
mean corpuscular volume
2
4
4
98.1
reticulocyte measurement
3
4
6
97.8
mean reticulocyte volume
1
4
4
96.5
red blood cell distribution width
4
2
4
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
98.8
mean corpuscular volume
4
98.1
reticulocyte measurement
6
97.8
mean reticulocyte volume
4
96.5
red blood cell distribution width
4
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
upstream binding transcription factor, RNA polymerase I
454726
Macaque
upstream binding transcription factor, RNA polymerase I
711597
Mouse
MGI:98512
21429
Rat
RGD:3927
25574
Dog
upstream binding transcription factor, RNA polymerase I
480503
Species
Name
OMA
EggNOG
Inparanoid
Chimp
upstream binding transcription factor, RNA polymerase I
Macaque
upstream binding transcription factor, RNA polymerase I
Mouse
Rat
Dog
upstream binding transcription factor, RNA polymerase I
Publication Statistics
PubMed Score 242.81
PubMed score by year
PubTator Score 162.79
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title