You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UBR5
E3 ubiquitin-protein ligase UBR5

Protein Summary
Description
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. This gene encodes a progestin-induced protein, whi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220959
  • ENSP00000220959
  • ENSG00000104517
  • ENST00000520539
  • ENSP00000429084

Symbol
  • EDD
  • EDD1
  • HYD
  • KIAA0896
  • DD5
  • EDD
  • HYD
  • EDD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
biological process
0.91
transcription factor binding site profile
0.91
protein domain
0.85
microRNA
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.59   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.59   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (158)
CALR3
Tbio
Novelty:  0.04510989
p_int:  0.979913988
p_ni:  0.020086012
Score:  0.286
Data Source:  BioPlex,STRINGDB
PPL
Tbio
Novelty:  0.00684645
p_int:  0.954937759
p_ni:  0.045062241
Data Source:  BioPlex
PDGFD
Tbio
Novelty:  0.00799996
p_int:  0.94359213
p_ni:  0.05640787
Data Source:  BioPlex
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.935744643
p_ni:  0.064255357
Score:  0.185
Data Source:  BioPlex,STRINGDB
DDX28
Tbio
Family:  Enzyme
Novelty:  0.16760542
p_int:  0.933824916
p_ni:  0.066175084
Score:  0.239
Data Source:  BioPlex,STRINGDB
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
p_int:  0.93180559
p_ni:  0.06819441
Data Source:  BioPlex
LYZL1
Tbio
Family:  Enzyme
Novelty:  0.10945096
p_int:  0.847260961
p_ni:  0.152739039
Data Source:  BioPlex
PRMT2
Tbio
Family:  Epigenetic
Novelty:  0.04121581
p_int:  0.83399349
p_ni:  0.16600651
Data Source:  BioPlex
PRSS37
Tdark
Family:  Enzyme
Novelty:  0.40482351
p_int:  0.82796005
p_ni:  0.172039949
Score:  0.169
Data Source:  BioPlex,STRINGDB
STX11
Tbio
Novelty:  0.01670743
p_int:  0.81545006
p_ni:  0.18454994
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
2
2
78.6
mean corpuscular volume
2
2
2
64.2
C-reactive protein measurement
3
2
3
53.8
mathematical ability
2
2
2
46.5
red blood cell density measurement
1
1
1
44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
78.6
mean corpuscular volume
2
64.2
C-reactive protein measurement
3
53.8
mathematical ability
2
46.5
red blood cell density measurement
1
44
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3 component n-recognin 5
VGNC:10225
464322
Macaque
ubiquitin protein ligase E3 component n-recognin 5
707163
Mouse
MGI:1918040
70790
Rat
RGD:621236
117060
Dog
ubiquitin protein ligase E3 component n-recognin 5
VGNC:48092
475055
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3 component n-recognin 5
Macaque
ubiquitin protein ligase E3 component n-recognin 5
Mouse
Rat
Dog
ubiquitin protein ligase E3 component n-recognin 5
Publication Statistics
PubMed Score 238.59
PubMed score by year
PubTator Score 170.89
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title