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Tbio
UBR3
E3 ubiquitin-protein ligase UBR3

Protein Summary
Description
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272793
  • ENSP00000272793
  • ENSG00000144357
  • ENST00000418381
  • ENSP00000396068

Symbol
  • KIAA2024
  • ZNF650
  • ZNF650
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
microRNA
0.69
small molecule perturbation
0.68
tissue sample
0.67
transcription factor binding site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.46   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.46   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
ZP2
Tbio
Novelty:  0.00310166
p_int:  0.999970834
p_ni:  0.000029166
Data Source:  BioPlex
IFNA8
Tbio
Novelty:  0.0310922
p_int:  0.999969167
p_ni:  0.000030833
Data Source:  BioPlex
IFNA21
Tbio
Novelty:  0.00581034
p_int:  0.999958465
p_ni:  0.000041535
Data Source:  BioPlex
FAHD1
Tbio
Family:  Enzyme
Novelty:  0.07873941
p_int:  0.999907434
p_ni:  0.000092566
Data Source:  BioPlex
IFNA7
Tbio
Novelty:  0.14618009
p_int:  0.999266517
p_ni:  0.000733483
Data Source:  BioPlex
CRP
Tbio
Novelty:  0.00001517
p_int:  0.999129546
p_ni:  0.000870454
Data Source:  BioPlex
C16orf45
Tbio
Novelty:  0.00913059
p_int:  0.998353351
p_ni:  0.001646649
Data Source:  BioPlex
TEX45
Tdark
Novelty:  5.55785981
p_int:  0.998103876
p_ni:  0.001896124
Data Source:  BioPlex
IFNA5
Tbio
Novelty:  0.02838784
p_int:  0.99742976
p_ni:  0.00257024
Score:  0.217
Data Source:  BioPlex,STRINGDB
TBRG1
Tbio
Novelty:  0.02003439
p_int:  0.997070866
p_ni:  0.002929133
p_wrong:  1e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
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1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
35.8
platelet crit
1
1
1
35.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
35.8
platelet crit
1
35.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1861100
68795
Rat
RGD:1565257
311115
Dog
ubiquitin protein ligase E3 component n-recognin 3 (putative)
VGNC:53111
478789
Horse
ubiquitin protein ligase E3 component n-recognin 3 (putative)
VGNC:51495
100063165
Cow
ubiquitin protein ligase E3 component n-recognin 3 (putative)
537932
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ubiquitin protein ligase E3 component n-recognin 3 (putative)
Horse
ubiquitin protein ligase E3 component n-recognin 3 (putative)
Cow
ubiquitin protein ligase E3 component n-recognin 3 (putative)
Publication Statistics
PubMed Score 10.46
PubMed score by year
PubTator Score 5.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title