UBP1
Upstream-binding protein 1
Protein Summary
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
- ENST00000283628
- ENSP00000283628
- ENSG00000153560
- ENST00000283629
- ENSP00000283629
- ENST00000447368
- ENSP00000395558
- LBP1
- LBP1A
- LBP1B
- LBP-1B
- LBP-1a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.88 | ||
transcription factor binding site profile | 0.86 | ||
transcription factor perturbation | 0.74 | ||
hub protein | 0.71 | ||
transcription factor | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 88.59 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 271 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 88.59 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 271 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (47)
LAMTOR5
Novelty: 0.003692
p_int: 0.999988787
p_ni: 0.000011191
p_wrong: 2.3e-8
Data Source: BioPlex
JAK2
Family: Kinase
Novelty: 0.00022894
p_int: 0.999988525
p_ni: 0.000011455
p_wrong: 1.9e-8
Score: 0.248
Data Source: BioPlex,STRINGDB
ANKRD29
Novelty: 1.29202649
p_int: 0.999975929
p_ni: 0.000024071
Score: 0.816
Data Source: BioPlex,STRINGDB
BRD4
Family: Epigenetic
Novelty: 0.0013933
p_int: 0.999954152
p_ni: 0.000045817
p_wrong: 3.1e-8
Data Source: BioPlex
STK35
Family: Kinase
Novelty: 0.19556072
p_int: 0.999593298
p_ni: 0.0004067
p_wrong: 2e-9
Score: 0.747
Data Source: BioPlex,STRINGDB
EVL
Novelty: 0.03533257
p_int: 0.999385589
p_ni: 0.000614407
p_wrong: 4e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
PRMT6
Family: Epigenetic
Novelty: 0.01734208
p_int: 0.999287909
p_ni: 0.000348554
p_wrong: 0.000363538
Score: 0.752
Data Source: BioPlex,STRINGDB
HINT3
Novelty: 1.14285714
p_int: 0.995089597
p_ni: 0.004119532
p_wrong: 0.000790871
Data Source: BioPlex
FAM19A3
Novelty: 0.37183557
p_int: 0.989437764
p_ni: 0.010546862
p_wrong: 0.000015374
Score: 0.2
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (5)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 2 | 2 | 73.6 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 42.3 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 33.1 | |||||
BMI-adjusted waist circumference | 1 | 2 | 2 | 27.2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 73.6 | |||||
alkaline phosphatase measurement | 1 | 42.3 | |||||
C-reactive protein measurement | 1 | 33.1 | |||||
BMI-adjusted waist circumference | 2 | 27.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | upstream binding protein 1 | VGNC:48922 | 460257 | |||||
Macaque | upstream binding protein 1 | 706283 | ||||||
Mouse | MGI:104889 | 22221 | ||||||
Rat | RGD:1564700 | 301038 | ||||||
Dog | upstream binding protein 1 | VGNC:52909 | 485572 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | upstream binding protein 1 | |||||
Macaque | upstream binding protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | upstream binding protein 1 | |||||
Publication Statistics
PubMed Score 88.59
PubMed score by year
PubTator Score 13.21
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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