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Tbio
UBP1
Upstream-binding protein 1

Protein Summary
Description
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283628
  • ENSP00000283628
  • ENSG00000153560
  • ENST00000283629
  • ENSP00000283629
  • ENST00000447368
  • ENSP00000395558

Symbol
  • LBP1
  • LBP1A
  • LBP1B
  • LBP-1B
  • LBP-1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor binding site profile
0.86
transcription factor perturbation
0.74
hub protein
0.71
transcription factor
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.59   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.59   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
TFCP2
Tbio
Family:  TF
Novelty:  0.00687548
p_int:  1
Score:  0.84
Data Source:  BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.999988787
p_ni:  0.000011191
p_wrong:  2.3e-8
Data Source:  BioPlex
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
p_int:  0.999988525
p_ni:  0.000011455
p_wrong:  1.9e-8
Score:  0.248
Data Source:  BioPlex,STRINGDB
ANKRD29
Tdark
Novelty:  1.29202649
p_int:  0.999975929
p_ni:  0.000024071
Score:  0.816
Data Source:  BioPlex,STRINGDB
BRD4
Tchem
Family:  Epigenetic
Novelty:  0.0013933
p_int:  0.999954152
p_ni:  0.000045817
p_wrong:  3.1e-8
Data Source:  BioPlex
STK35
Tchem
Family:  Kinase
Novelty:  0.19556072
p_int:  0.999593298
p_ni:  0.0004067
p_wrong:  2e-9
Score:  0.747
Data Source:  BioPlex,STRINGDB
EVL
Tbio
Novelty:  0.03533257
p_int:  0.999385589
p_ni:  0.000614407
p_wrong:  4e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
PRMT6
Tchem
Family:  Epigenetic
Novelty:  0.01734208
p_int:  0.999287909
p_ni:  0.000348554
p_wrong:  0.000363538
Score:  0.752
Data Source:  BioPlex,STRINGDB
HINT3
Tdark
Novelty:  1.14285714
p_int:  0.995089597
p_ni:  0.004119532
p_wrong:  0.000790871
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.989437764
p_ni:  0.010546862
p_wrong:  0.000015374
Score:  0.2
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
73.6
alkaline phosphatase measurement
1
1
1
42.3
C-reactive protein measurement
1
1
1
33.1
BMI-adjusted waist circumference
1
2
2
27.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
73.6
alkaline phosphatase measurement
1
42.3
C-reactive protein measurement
1
33.1
BMI-adjusted waist circumference
2
27.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
upstream binding protein 1
VGNC:48922
460257
Macaque
upstream binding protein 1
706283
Mouse
MGI:104889
22221
Rat
RGD:1564700
301038
Dog
upstream binding protein 1
VGNC:52909
485572
Species
Name
OMA
EggNOG
Inparanoid
Chimp
upstream binding protein 1
Macaque
upstream binding protein 1
Mouse
Rat
Dog
upstream binding protein 1
Publication Statistics
PubMed Score 88.59
PubMed score by year
PubTator Score 13.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title