Pharos : Target Details

Tbio

Protein Summary

Uniprot Accession IDs

Gene Name

UBN2

Ensembl ID

ENST00000473989
ENSP00000418648
ENSG00000157741

Symbol

KIAA2030

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81

kinase perturbation	0.76

microRNA	0.7

tissue	0.64

transcription factor binding site profile	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.36 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 81 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.36 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 81 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (70)

Explore Interacting Targets

1 – 10 of 70

See Interactions on String-DB

ASF1B

Tbio

Novelty: 0.05716701

p_int: 0.999999983

p_ni: 1.7e-8

p_wrong: 1e-9

Score: 0.266

Data Source: BioPlex,STRINGDB

ASF1A

Tchem

Novelty: 0.02544466

p_int: 0.999999982

p_ni: 1.7e-8

p_wrong: 1e-9

Score: 0.578

Data Source: BioPlex,STRINGDB

CDX1

Tbio

Family: TF

Novelty: 0.00815821

p_int: 0.999858599

p_ni: 0.000141399

p_wrong: 2e-9

Data Source: BioPlex

HMGA1

Tbio

Family: TF

Novelty: 0.00185669

p_int: 0.999590408

p_ni: 0.000409592

Data Source: BioPlex

LANCL1

Tbio

Novelty: 0.06479031

p_int: 0.999422624

p_ni: 0.000577374

p_wrong: 1e-9

Score: 0.523

Data Source: BioPlex,STRINGDB

TFAP4

Tbio

Family: TF

Novelty: 0.03155887

p_int: 0.99938627

p_ni: 0.000613378

p_wrong: 3.52e-7

Score: 0.195

Data Source: BioPlex,STRINGDB

TEAD2

Tbio

Family: TF

Novelty: 0.02487024

p_int: 0.991286065

p_ni: 0.008707913

p_wrong: 0.000006022

Score: 0.187

Data Source: BioPlex,STRINGDB

ALX3

Tbio

Family: TF

Novelty: 0.02711914

p_int: 0.9633365

p_ni: 0.014387538

p_wrong: 0.022275962

Score: 0.167

Data Source: BioPlex,STRINGDB

MEF2B

Tbio

Family: TF

Novelty: 0.03094093

p_int: 0.947954582

p_ni: 0.020858544

p_wrong: 0.031186874

Data Source: BioPlex

H3F3A

Tbio

Novelty: 0.00508186

Score: 0.758

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Components (2)

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Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
nucleoplasm	Inferred from Direct Assay (IDA)	HPA

extracellular space	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (5)

Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
left ventricular diastolic function measurement	EFO_0008204	1	1	0	1.7	21.5

high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		17.8

comparative body size at age 10, self-reported	EFO_0009819	1	1	1		17.8

body mass index	EFO_0004340	1	1	1		17.4

body height	EFO_0004339	1	1	1		11.5

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
left ventricular diastolic function measurement	EFO_0008204	0	1.7	21.5

high density lipoprotein cholesterol measurement	EFO_0004612	1		17.8

comparative body size at age 10, self-reported	EFO_0009819	1		17.8

body mass index	EFO_0004340	1		17.4

body height	EFO_0004339	1		11.5

Beta Count

Odds Ratio

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UniProt Keyword

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No Header	No Header
Acetylation

Alternative splicing

Complete proteome

Isopeptide bond

Phosphoprotein

Polymorphism

Reference proteome

Ubl conjugation

GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Chimp	ubinuclein 2	VGNC:4557	463770

Macaque	ubinuclein 2		711019

Mouse	ubinuclein 2	MGI:2444236	320538

Rat	ubinuclein 2	RGD:1310722	312248

Dog	ubinuclein 2	VGNC:48082	482776

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ubinuclein 2

Macaque	ubinuclein 2

Mouse	ubinuclein 2

Rat	ubinuclein 2

Dog	ubinuclein 2

Publication Statistics

PubMed Score 11.36

PubMed score by year

PubTator Score 1.20

PubTator score by year

Related Publications

Text Mined References (6)

Items per page:

0 of 0

PMID	Year	Title