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Tchem
UBLCP1
Ubiquitin-like domain-containing CTD phosphatase 1

Protein Summary
Description
Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296786
  • ENSP00000296786
  • ENSG00000164332

Symbol
  • CPUB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor perturbation
0.8
protein domain
0.73
transcription factor binding site profile
0.72
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (120)
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.999970167
p_ni:  0.000029139
p_wrong:  6.95e-7
Data Source:  BioPlex
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.999842554
p_ni:  0.000107786
p_wrong:  0.00004966
Score:  0.193
Data Source:  BioPlex,STRINGDB
NUDT6
Tbio
Novelty:  0.03648851
p_int:  0.996663745
p_ni:  0.003292499
p_wrong:  0.000043756
Score:  0.28
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.996410935
p_ni:  0.000088036
p_wrong:  0.003501029
Data Source:  BioPlex
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
Score:  0.959
Data Source:  STRINGDB
PSMD3
Tbio
Family:  Enzyme
Novelty:  0.03106272
Score:  0.957
Data Source:  STRINGDB
PSMC1
Tbio
Family:  Enzyme
Novelty:  0.04631888
Score:  0.952
Data Source:  STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
Score:  0.952
Data Source:  STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
Score:  0.941
Data Source:  STRINGDB
PSMC2
Tbio
Family:  Enzyme
Novelty:  0.08240664
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
8
0
1.3
98
mean platelet volume
4
3
4
97.9
1
3
0
1.4
91.9
platelet count
2
2
2
88.2
2
2
0
3.8
77.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
98
mean platelet volume
4
97.9
0
1.4
91.9
platelet count
2
88.2
0
3.8
77.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like domain containing CTD phosphatase 1
VGNC:13611
471722
Macaque
ubiquitin like domain containing CTD phosphatase 1
694476
Mouse
MGI:1933105
79560
Rat
RGD:1310386
360514
Dog
ubiquitin like domain containing CTD phosphatase 1
VGNC:48080
489153
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like domain containing CTD phosphatase 1
Macaque
ubiquitin like domain containing CTD phosphatase 1
Mouse
Rat
Dog
ubiquitin like domain containing CTD phosphatase 1
Publication Statistics
PubMed Score 8.19
PubMed score by year
PubTator Score 5.67
PubTator score by year
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Related Publications
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PMID
Year
Title