You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UBE4B
Ubiquitin conjugation factor E4 B

Protein Summary
Description
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript var ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253251
  • ENSP00000253251
  • ENSG00000130939
  • ENST00000343090
  • ENSP00000343001

Symbol
  • HDNB1
  • KIAA0684
  • UFD2
  • E4
  • UFD2
  • HDNB1
  • UBOX3
  • UFD2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
co-expressed gene
0.99
transcription factor
0.85
transcription factor binding site profile
0.84
kinase perturbation
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.85   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.85   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (182)
UBL7
Tdark
Novelty:  0.20935024
p_int:  1
Score:  0.928
Data Source:  BioPlex,STRINGDB
OR7A5
Tdark
Family:  oGPCR
Novelty:  1.72860482
p_int:  0.999978065
p_ni:  0.000021935
Data Source:  BioPlex
PCDHA8
Tdark
Novelty:  0.57189179
p_int:  0.999965874
p_ni:  0.000034126
Data Source:  BioPlex
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
p_int:  0.99932512
p_ni:  0.00067488
Score:  0.992
Data Source:  BioPlex,STRINGDB
CDC25A
Tchem
Family:  Enzyme
Novelty:  0.00250149
p_int:  0.999266156
p_ni:  0.000733841
p_wrong:  3e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
NLRP10
Tbio
Novelty:  0.0472395
p_int:  0.998220321
p_ni:  0.001771531
p_wrong:  0.000008148
Data Source:  BioPlex
RAD23B
Tbio
Novelty:  0.00672104
p_int:  0.989634546
p_ni:  0.010153704
p_wrong:  0.000211749
Score:  0.978
Data Source:  BioPlex,STRINGDB
LRRC73
Tdark
Novelty:  48
p_int:  0.907843433
p_ni:  0.08996246
p_wrong:  0.002194107
Data Source:  BioPlex
UBQLN1
Tbio
Novelty:  0.00921991
Score:  0.99
Data Source:  STRINGDB
TP73
Tbio
Family:  TF
Novelty:  0.00667737
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Ubiquitin mediated proteolysis
KEGG
Protein processing in endoplasmic reticulum
Name
Explore in Pharos
Explore in Source
Ubiquitin mediated proteolysis
Protein processing in endoplasmic reticulum
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
2
4
95.6
platelet count
1
1
1
74.6
BMI-adjusted hip circumference
2
5
5
71.3
body fat distribution
2
1
3
65.5
BMI-adjusted waist circumference
2
1
2
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
95.6
platelet count
1
74.6
BMI-adjusted hip circumference
5
71.3
body fat distribution
3
65.5
BMI-adjusted waist circumference
2
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitination factor E4B
VGNC:1714
457924
Macaque
ubiquitination factor E4B
713348
Mouse
MGI:1927086
63958
Rat
RGD:1304738
298652
Dog
ubiquitination factor E4B
VGNC:48073
479603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitination factor E4B
Macaque
ubiquitination factor E4B
Mouse
Rat
Dog
ubiquitination factor E4B
Publication Statistics
PubMed Score 68.85
PubMed score by year
PubTator Score 50.25
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title