You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UBE4A
Ubiquitin conjugation factor E4 A

Protein Summary
Description
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252108
  • ENSP00000252108
  • ENSG00000110344
  • ENST00000431736
  • ENSP00000387362

Symbol
  • KIAA0126
  • E4
  • UFD2
  • UBOX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
histone modification site profile
0.81
transcription factor binding site profile
0.8
cell type or tissue
0.68
kinase perturbation
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.34   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.34   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (387)
UBXN4
Tbio
Novelty:  0.16206743
p_int:  0.999999911
p_ni:  7.7e-8
p_wrong:  1.2e-8
Score:  0.891
Data Source:  BioPlex,STRINGDB
TMEM134
Tdark
Novelty:  0.42629221
p_int:  0.999999858
p_ni:  1.41e-7
p_wrong:  2e-9
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.999999539
p_ni:  4.6e-7
p_wrong:  1e-9
Data Source:  BioPlex
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.99999342
p_ni:  0.000006577
p_wrong:  3e-9
Score:  0.305
Data Source:  BioPlex,STRINGDB
B4GALT3
Tbio
Family:  Enzyme
Novelty:  0.04015046
p_int:  0.994966428
p_ni:  0.005033521
p_wrong:  5.1e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.989331723
p_ni:  0.010668276
p_wrong:  2e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.988507764
p_ni:  0.01093946
p_wrong:  0.000552776
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.964852558
p_ni:  0.03514744
p_wrong:  1e-9
Data Source:  BioPlex
PARP16
Tchem
Family:  Enzyme
Novelty:  0.09651799
p_int:  0.962806659
p_ni:  0.03719334
p_wrong:  2e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.932606972
p_ni:  0.067239725
p_wrong:  0.000153303
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
64.2
hemoglobin measurement
2
1
2
58.4
serum gamma-glutamyl transferase measurement
1
1
1
35
apolipoprotein A 1 measurement
1
1
1
35
wellbeing measurement
2
1
2
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
64.2
hemoglobin measurement
2
58.4
serum gamma-glutamyl transferase measurement
1
35
apolipoprotein A 1 measurement
1
35
wellbeing measurement
2
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitination factor E4A
699836
Mouse
MGI:2154580
140630
Rat
RGD:1303173
315608
Dog
ubiquitination factor E4A
VGNC:48072
479418
Horse
ubiquitination factor E4A
VGNC:24733
100062986
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitination factor E4A
Mouse
Rat
Dog
ubiquitination factor E4A
Horse
ubiquitination factor E4A
Publication Statistics
PubMed Score 36.34
PubMed score by year
PubTator Score 355.62
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title