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Tbio
UBE3D
E3 ubiquitin-protein ligase E3D

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369747
  • ENSP00000358762
  • ENSG00000118420

Symbol
  • C6orf157
  • H10BH
  • UBE2CBP
  • H10BH
  • UBE2CBP
  • YJR141W
  • C6orf157
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.7
tissue sample
0.69
cell type or tissue
0.65
virus perturbation
0.64
transcription factor
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (306)
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999999973
p_ni:  1.9e-8
p_wrong:  8e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
LMO1
Tbio
Novelty:  0.01670419
p_int:  0.999999972
p_ni:  2.8e-8
Data Source:  BioPlex
MEMO1
Tbio
Novelty:  0.0506558
p_int:  0.999610776
p_ni:  0.000389132
p_wrong:  9.3e-8
Score:  0.6
Data Source:  BioPlex,STRINGDB
GTPBP2
Tbio
Novelty:  0.10282876
p_int:  0.996139391
p_ni:  0.003860609
Score:  0.177
Data Source:  BioPlex,STRINGDB
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.989444555
p_ni:  0.010555445
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.985158743
p_ni:  0.014841255
p_wrong:  2e-9
Data Source:  BioPlex
HSP90AB4P
Tdark
p_int:  0.973561121
p_ni:  0.026438879
Data Source:  BioPlex
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
p_int:  0.960729437
p_ni:  0.020931012
p_wrong:  0.018339551
Score:  0.231
Data Source:  BioPlex,STRINGDB
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.960463216
p_ni:  0.026362898
p_wrong:  0.013173885
Data Source:  BioPlex
C1QTNF9B
Tdark
Novelty:  0.7643008
p_int:  0.959703544
p_ni:  0.021662724
p_wrong:  0.018633731
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
4
79.7
1
1
0
2.1
49.5
vitamin D measurement
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
79.7
0
2.1
49.5
vitamin D measurement
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3D
VGNC:3782
462851
Macaque
ubiquitin protein ligase E3D
694910
Mouse
MGI:1917598
70348
Rat
RGD:1306773
315863
Dog
ubiquitin protein ligase E3D
VGNC:48071
481900
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin protein ligase E3D
Macaque
ubiquitin protein ligase E3D
Mouse
Rat
Dog
ubiquitin protein ligase E3D
Publication Statistics
PubMed Score 2.93
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title