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Tbio
UBE2V1
Ubiquitin-conjugating enzyme E2 variant 1

Protein Summary
Description
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through tr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340309
  • ENSP00000340305
  • ENSG00000244687
  • ENST00000371657
  • ENSP00000360720
  • ENST00000371674
  • ENSP00000360739
  • ENST00000371677
  • ENSP00000360742
  • ENST00000415862
  • ENSP00000407770

Symbol
  • CROC1
  • UBE2V
  • UEV1
  • CROC1B
  • CROC-1B
  • KUA-UEV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
cellular component
0.78
transcription factor binding site profile
0.78
pathway
0.73
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.44   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.44   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0