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Tdark
UBE2U
Ubiquitin-conjugating enzyme E2 U

Protein Summary
Description
Catalyzes the covalent attachment of ubiquitin to other proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371076
  • ENSP00000360116
  • ENSG00000177414
  • ENST00000611228
  • ENSP00000481174
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
gene perturbation
0.93
cellular component
0.61
cell line
0.6
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (310)
MVB12A
Tbio
Novelty:  0.09794
p_int:  0.975863702
p_ni:  0.024131813
p_wrong:  0.000004485
Score:  0.837
Data Source:  BioPlex,STRINGDB
VPS28
Tbio
Novelty:  0.02927315
p_int:  0.945057042
p_ni:  0.054652325
p_wrong:  0.000290633
Score:  0.814
Data Source:  BioPlex,STRINGDB
UBE2Z
Tbio
Novelty:  0.11461616
Score:  0.977
Data Source:  STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
Score:  0.975
Data Source:  STRINGDB
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
Score:  0.974
Data Source:  STRINGDB
UBOX5
Tbio
Novelty:  0.37436118
Score:  0.97
Data Source:  STRINGDB
UBE2V1
Tbio
Novelty:  0.01642178
Score:  0.961
Data Source:  STRINGDB
TRIP12
Tbio
Family:  Enzyme
Novelty:  0.03433452
Score:  0.959
Data Source:  STRINGDB
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
Score:  0.959
Data Source:  STRINGDB
UBE2J2
Tbio
Novelty:  0.2367348
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
21.5
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 U
VGNC:9905
469342
Macaque
ubiquitin conjugating enzyme E2 U (putative)
697545
Mouse
MGI:3588216
381534
Rat
RGD:1565480
500511
Dog
ubiquitin conjugating enzyme E2 U
VGNC:53639
609932
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 U
Macaque
ubiquitin conjugating enzyme E2 U (putative)
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 U
Publication Statistics
PubMed Score 2.39
PubMed score by year
PubTator Score 0.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title