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Tbio
UBE2Q2
Ubiquitin-conjugating enzyme E2 Q2

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267938
  • ENSP00000267938
  • ENSG00000140367
  • ENST00000561851
  • ENSP00000456229
  • ENST00000569423
  • ENSP00000456324
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
transcription factor binding site profile
0.72
transcription factor
0.7
tissue
0.66
histone modification site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.98   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.98   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (303)
UBE2Q1
Tbio
Novelty:  0.06489765
p_int:  0.999999917
p_ni:  4e-9
p_wrong:  7.9e-8
Score:  0.901
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.981238606
p_ni:  0.018429051
p_wrong:  0.000332343
Data Source:  BioPlex
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
Score:  0.951
Data Source:  STRINGDB
UBE2B
Tchem
Novelty:  0.01578275
Score:  0.95
Data Source:  STRINGDB
UBE2A
Tbio
Novelty:  0.01670792
Score:  0.95
Data Source:  STRINGDB
UBE2Z
Tbio
Novelty:  0.11461616
Score:  0.95
Data Source:  STRINGDB
UBE2J2
Tbio
Novelty:  0.2367348
Score:  0.949
Data Source:  STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
Score:  0.944
Data Source:  STRINGDB
FBXO22
Tbio
Novelty:  0.12033872
Score:  0.942
Data Source:  STRINGDB
UBE3B
Tbio
Family:  Enzyme
Novelty:  0.06274049
Score:  0.942
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
6
7
10.4
97.8
creatinine measurement
4
4
6
96.5
urate measurement
3
4
5
92.2
serum urea measurement
1
3
3
91.7
hematocrit
1
2
2
76.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
10.4
97.8
creatinine measurement
6
96.5
urate measurement
5
92.2
serum urea measurement
3
91.7
hematocrit
2
76.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 Q2
VGNC:3520
453772
Macaque
ubiquitin conjugating enzyme E2 Q2
100428498
Mouse
MGI:2388672
109161
Dog
ubiquitin conjugating enzyme E2 Q2
VGNC:48062
478374
Horse
ubiquitin conjugating enzyme E2 Q2
VGNC:24726
100050645
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 Q2
Macaque
ubiquitin conjugating enzyme E2 Q2
Mouse
Dog
ubiquitin conjugating enzyme E2 Q2
Horse
ubiquitin conjugating enzyme E2 Q2
Publication Statistics
PubMed Score 8.98
PubMed score by year
PubTator Score 5.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title