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Tbio
UBE2E2
Ubiquitin-conjugating enzyme E2 E2

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396703
  • ENSP00000379931
  • ENSG00000182247
  • ENST00000425792
  • ENSP00000401053

Symbol
  • UBCH8
  • UBCH8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
histone modification site profile
0.81
virus perturbation
0.76
kinase perturbation
0.71
trait
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.34   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.34   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (388)
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
p_int:  1
Score:  0.934
Data Source:  BioPlex,STRINGDB
DET1
Tbio
Novelty:  0.01138079
p_int:  0.999999252
p_ni:  7.09e-7
p_wrong:  3.9e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
USP15
Tbio
Family:  Enzyme
Novelty:  0.0208842
p_int:  0.999762543
p_ni:  0.000237457
Score:  0.415
Data Source:  BioPlex,STRINGDB
OTUB1
Tbio
Family:  Enzyme
Novelty:  0.00536726
p_int:  0.99867488
p_ni:  0.00132512
Score:  0.545
Data Source:  BioPlex,STRINGDB
UBA7
Tbio
Novelty:  0.01923008
Score:  0.987
Data Source:  STRINGDB
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
Score:  0.981
Data Source:  STRINGDB
HERC5
Tbio
Family:  Enzyme
Novelty:  0.01726248
Score:  0.98
Data Source:  STRINGDB
UBA1
Tbio
Novelty:  0.00419724
Score:  0.979
Data Source:  STRINGDB
SIAH1
Tbio
Family:  Enzyme
Novelty:  0.00831224
Score:  0.973
Data Source:  STRINGDB
TRAF7
Tbio
Family:  Enzyme
Novelty:  0.02437761
Score:  0.972
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
10
9
4
1.1
97.6
hematocrit
2
2
2
74.6
Drugs used in diabetes use measurement
1
1
1
65.5
HbA1c measurement
1
1
1
54.4
hemoglobin measurement
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
97.6
hematocrit
2
74.6
Drugs used in diabetes use measurement
1
65.5
HbA1c measurement
1
54.4
hemoglobin measurement
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitin-conjugating enzyme E2E 2
699101
Mouse
MGI:2384997
218793
Dog
ubiquitin conjugating enzyme E2 E1
VGNC:52908
477048
Pig
ubiquitin-conjugating enzyme E2 E1
102160336
Opossum
ubiquitin conjugating enzyme E2 E1 [Source:HGNC Symbol;Acc:HGNC:12477]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitin-conjugating enzyme E2E 2
Mouse
Dog
ubiquitin conjugating enzyme E2 E1
Pig
ubiquitin-conjugating enzyme E2 E1
Opossum
ubiquitin conjugating enzyme E2 E1 [Source:HGNC Symbol;Acc:HGNC:12477]
Publication Statistics
PubMed Score 26.34
PubMed score by year
PubTator Score 12.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title