Tbio UBE2D4 Ubiquitin-conjugating enzyme E2 D4

Protein Summary

Description

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.

Uniprot Accession IDs

• Q9Y2X8
• A4D1V0

Gene Name

• UBE2D4

Ensembl ID

• ENST00000222402
• ENSP00000222402
• ENSG00000078967

Symbol

• UBCH5D
• HBUCE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
molecular function	0.91
virus perturbation	0.83
histone modification site profile	0.82
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-conjugating Enzyme E2 D4

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-conjugating Enzyme E2 D4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.08   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.08   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0