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Tchem
UBE2D3
Ubiquitin-conjugating enzyme E2 D3

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321805
  • ENSP00000318494
  • ENSG00000109332
  • ENST00000338145
  • ENSP00000337208
  • ENST00000343106
  • ENSP00000345285
  • ENST00000349311
  • ENSP00000344069
  • ENST00000357194
  • ENSP00000349722
  • ENST00000394801
  • ENSP00000378280
  • ENST00000394803
  • ENSP00000378282
  • ENST00000394804
  • ENSP00000378283
  • ENST00000453744
  • ENSP00000396901

Symbol
  • UBC5C
  • UBCH5C
  • UBC4/5
  • UBCH5C
  • E2(17)KB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
transcription factor perturbation
0.98
kinase perturbation
0.95
biological process
0.93


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.45   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.45   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (488)
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
p_int:  0.998533934
p_ni:  0.001466066
Score:  0.954
Data Source:  BioPlex,STRINGDB
UBA1
Tbio
Novelty:  0.00419724
Score:  0.994
Data Source:  STRINGDB
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
Score:  0.992
Data Source:  STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
Score:  0.992
Data Source:  Reactome,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.992
Data Source:  STRINGDB
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
Score:  0.99
Data Source:  STRINGDB
BIRC3
Tchem
Novelty:  0.00189613
Score:  0.988
Data Source:  Reactome,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.988
Data Source:  STRINGDB
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
Score:  0.987
Data Source:  STRINGDB
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (48)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Cellular response to hypoxia
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
4
3
6.3
91.5
testosterone measurement
2
2
2
79.8
diastolic blood pressure
1
1
1
73.6
alkaline phosphatase measurement
1
1
1
64.4
creatinine measurement
1
1
1
59.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
6.3
91.5
testosterone measurement
2
79.8
diastolic blood pressure
1
73.6
alkaline phosphatase measurement
1
64.4
creatinine measurement
1
59.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913355
66105
Rat
RGD:619912
81920
Chicken
ubiquitin conjugating enzyme E2 D3
CGNC:51809
422713
C. elegans
178006
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Chicken
ubiquitin conjugating enzyme E2 D3
C. elegans
Publication Statistics
PubMed Score 40.45
PubMed score by year
PubTator Score 24.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title