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Tbio
UBE2D2
Ubiquitin-conjugating enzyme E2 D2

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-media ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398733
  • ENSP00000381717
  • ENSG00000131508
  • ENST00000398734
  • ENSP00000381718
  • ENST00000505548
  • ENSP00000424941
  • ENST00000511725
  • ENSP00000429613

Symbol
  • PUBC1
  • UBC4
  • UBC5B
  • UBCH4
  • UBCH5B
  • UBC4
  • PUBC1
  • UBCH4
  • UBC4/5
  • UBCH5B
  • E2(17)KB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
molecular function
0.91
transcription factor perturbation
0.8
transcription factor binding site profile
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.81   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.81   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (505)
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
p_int:  1
Score:  0.994
Data Source:  BioPlex,STRINGDB
OTUB1
Tbio
Family:  Enzyme
Novelty:  0.00536726
p_int:  0.999949844
p_ni:  0.000050156
Score:  0.783
Data Source:  BioPlex,STRINGDB
RNF10
Tbio
Novelty:  0.09086567
p_int:  0.999942151
p_ni:  0.000006294
p_wrong:  0.000051556
Score:  0.421
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999857911
p_ni:  0.000142089
Score:  0.997
Data Source:  BioPlex,STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
p_int:  0.999259516
p_ni:  0.000740484
Score:  0.917
Data Source:  BioPlex,STRINGDB
THAP8
Tdark
Family:  TF
Novelty:  3.10152067
p_int:  0.990673703
p_ni:  0.007664203
p_wrong:  0.001662094
Score:  0.219
Data Source:  BioPlex,STRINGDB
NKD2
Tbio
Novelty:  0.04042015
p_int:  0.974249295
p_ni:  0.015781272
p_wrong:  0.009969433
Score:  0.189
Data Source:  BioPlex,STRINGDB
SPRY2
Tbio
Novelty:  0.00884945
p_int:  0.974249295
p_ni:  0.015781272
p_wrong:  0.009969433
Score:  0.188
Data Source:  BioPlex,STRINGDB
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.974249295
p_ni:  0.015781272
p_wrong:  0.009969433
Score:  0.177
Data Source:  BioPlex,STRINGDB
NFYA
Tbio
Family:  TF
Novelty:  0.00507094
p_int:  0.974249295
p_ni:  0.015781272
p_wrong:  0.009969433
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (42)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Cellular response to hypoxia
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Cellular response to hypoxia
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
88
response to radiation
1
2
0
2
82.8
mucositis
1
2
0
2
82.8
body height
2
2
2
76.7
body mass index
3
2
3
72.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
88
response to radiation
0
2
82.8
mucositis
0
2
82.8
body height
2
76.7
body mass index
3
72.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 D2
VGNC:4218
462108
Mouse
MGI:1930715
56550
Rat
RGD:1591897
641452
Rat
RGD:619912
81920
Dog
ubiquitin conjugating enzyme E2 D2
VGNC:48051
612742
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 D2
Mouse
Rat
Rat
Dog
ubiquitin conjugating enzyme E2 D2
Publication Statistics
PubMed Score 155.81
PubMed score by year
PubTator Score 48.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title