Tbio UBE2D1 Ubiquitin-conjugating enzyme E2 D1

Protein Summary

Description

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• P51668
• A6NLF6
• A8K786

Gene Name

• UBE2D1

Ensembl ID

• ENST00000373910
• ENSP00000363019
• ENSG00000072401

Symbol

• SFT
• UBC5A
• UBCH5
• UBCH5A
• SFT
• UBCH5
• UBC4/5
• UBCH5A
• E2(17)KB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
kinase perturbation	0.95
molecular function	0.91
virus perturbation	0.88
microRNA	0.7

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-conjugating Enzyme E2 D1

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-conjugating Enzyme E2 D1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.39   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 260   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.39   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0