UBE2B
Ubiquitin-conjugating enzyme E2 B
Protein Summary
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes ...more
- ENST00000265339
- ENSP00000265339
- ENSG00000119048
- RAD6B
- HR6B
- UBC2
- HHR6B
- RAD6B
- E2-17kDa
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
virus perturbation | 1 | ||
biological process | 0.99 | ||
disease perturbation | 0.96 | ||
molecular function | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.01 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 234 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.01 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 234 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 34
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (420)
RAD18
Family: Enzyme
Novelty: 0.00519213
p_int: 0.999920751
p_ni: 0.000079249
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RNF20
Family: Enzyme
Novelty: 0.01238827
p_int: 0.958298548
p_ni: 0.041701452
Score: 0.994
Data Source: BioPlex,STRINGDB
UBE2A
Novelty: 0.01670792
p_int: 0.891075445
p_ni: 0.108924555
Score: 0.961
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (17)
Reactome (12)
KEGG (1)
PathwayCommons (1)
UniProt (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | DNA Damage Bypass | ||||
Reactome | DNA Repair | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
DNA Damage Bypass | ||||
DNA Repair | ||||
Viral Interactions (0)
Gene Ontology Terms (43)
Functions (4)
Components (9)
Processes (30)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 1 | 1 | 1 | 6.5 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 1 | 6.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ubiquitin conjugating enzyme E2 B | VGNC:4217 | 462065 | |||||
Macaque | ubiquitin conjugating enzyme E2 B | 710678 | ||||||
Mouse | MGI:102944 | 22210 | ||||||
Dog | ubiquitin conjugating enzyme E2 B | 474683 | ||||||
Horse | ubiquitin conjugating enzyme E2 B | VGNC:24713 | 100062920 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ubiquitin conjugating enzyme E2 B | |||||
Macaque | ubiquitin conjugating enzyme E2 B | |||||
Mouse | ||||||
Dog | ubiquitin conjugating enzyme E2 B | |||||
Horse | ubiquitin conjugating enzyme E2 B | |||||
Publication Statistics
PubMed Score 64.01
PubMed score by year
PubTator Score 319.93
PubTator score by year
Related Publications
Text Mined References (50)
GeneRif Annotations (27)
Items per page:
0 of 0
PMID | Year | Title |
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