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Tchem
UBE2B
Ubiquitin-conjugating enzyme E2 B

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265339
  • ENSP00000265339
  • ENSG00000119048

Symbol
  • RAD6B
  • HR6B
  • UBC2
  • HHR6B
  • RAD6B
  • E2-17kDa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
biological process
0.99
disease perturbation
0.96
molecular function
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.01   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.01   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (420)
RAD18
Tbio
Family:  Enzyme
Novelty:  0.00519213
p_int:  0.999920751
p_ni:  0.000079249
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RNF20
Tbio
Family:  Enzyme
Novelty:  0.01238827
p_int:  0.958298548
p_ni:  0.041701452
Score:  0.994
Data Source:  BioPlex,STRINGDB
UBE2A
Tbio
Novelty:  0.01670792
p_int:  0.891075445
p_ni:  0.108924555
Score:  0.961
Data Source:  BioPlex,STRINGDB
UBE2V2
Tbio
Novelty:  0.01112479
Score:  0.996
Data Source:  Reactome,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
Score:  0.995
Data Source:  STRINGDB
RNF40
Tbio
Family:  Enzyme
Novelty:  0.07038528
Score:  0.994
Data Source:  STRINGDB
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
Score:  0.994
Data Source:  STRINGDB
UBE2V1
Tbio
Novelty:  0.01642178
Score:  0.991
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.989
Data Source:  STRINGDB
UBA1
Tbio
Novelty:  0.00419724
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
DNA Damage Bypass
DNA Repair
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
6.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 B
VGNC:4217
462065
Macaque
ubiquitin conjugating enzyme E2 B
710678
Mouse
MGI:102944
22210
Dog
ubiquitin conjugating enzyme E2 B
474683
Horse
ubiquitin conjugating enzyme E2 B
VGNC:24713
100062920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 B
Macaque
ubiquitin conjugating enzyme E2 B
Mouse
Dog
ubiquitin conjugating enzyme E2 B
Horse
ubiquitin conjugating enzyme E2 B
Publication Statistics
PubMed Score 64.01
PubMed score by year
PubTator Score 319.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title