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Tbio
UBD
Ubiquitin D

Protein Summary
Description
Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377050
  • ENSP00000366249
  • ENSG00000213886
  • ENST00000383547
  • ENSP00000373039
  • ENSG00000206468
  • ENST00000421519
  • ENSP00000396152
  • ENSG00000231968
  • ENST00000432676
  • ENSP00000410416
  • ENSG00000228913

Symbol
  • FAT10
  • FAT10
  • UBD-3
  • GABBR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
gene perturbation
0.67
biological term
0.63
biological process
0.6
cellular component
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.68   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.68   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (380)
NUB1
Tbio
Novelty:  0.00736082
p_int:  0.999999996
p_ni:  4e-9
Score:  0.741
Data Source:  BioPlex,Reactome,STRINGDB
NAA15
Tbio
Family:  Enzyme
Novelty:  0.00513055
p_int:  0.999172454
p_ni:  0.000827545
p_wrong:  1e-9
Data Source:  BioPlex
RABGGTA
Tdark
Family:  Enzyme
Novelty:  0.19962321
p_int:  0.873632338
p_ni:  0.126367662
Data Source:  BioPlex
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
Score:  0.989
Data Source:  STRINGDB
PSMA6
Tbio
Family:  Enzyme
Novelty:  0.01525994
Score:  0.974
Data Source:  STRINGDB
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
Score:  0.972
Data Source:  STRINGDB
PSMD11
Tbio
Family:  Enzyme
Novelty:  0.02148951
Score:  0.969
Data Source:  STRINGDB
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
Score:  0.968
Data Source:  STRINGDB
NEDD8
Tchem
Novelty:  0.00305343
Score:  0.967
Data Source:  STRINGDB
PSMD14
Tchem
Family:  Enzyme
Novelty:  0.01019285
Score:  0.967
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (128)
Items per page:
1 – 5 of 128
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
3
4
0
1.1
95.2
schizophrenia
3
4
0
1.1
95.2
schizophrenia
3
4
0
1.1
95.2
schizophrenia
3
4
0
1.1
95.2
4
5
4
1.1
86.6
Items per page:
1 – 5 of 128
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
0
1.1
95.2
schizophrenia
0
1.1
95.2
schizophrenia
0
1.1
95.2
schizophrenia
0
1.1
95.2
4
1.1
86.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1344410
24108
Rat
RGD:69418
29168
Horse
ubiquitin D
VGNC:49351
102149821
Opossum
ubiquitin D [Source:HGNC Symbol;Acc:HGNC:18795]
Platypus
ubiquitin D
100076123
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
ubiquitin D
Opossum
ubiquitin D [Source:HGNC Symbol;Acc:HGNC:18795]
Platypus
ubiquitin D
Publication Statistics
PubMed Score 217.68
PubMed score by year
PubTator Score 51.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title