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Tbio
UBAC1
Ubiquitin-associated domain-containing protein 1

Protein Summary
Description
Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371756
  • ENSP00000360821
  • ENSG00000130560

Symbol
  • GBDR1
  • KPC2
  • UBADC1
  • KPC2
  • GBDR1
  • UBADC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
virus perturbation
0.92
gene perturbation
0.9
cell type or tissue
0.81
transcription factor binding site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 929.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 929.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (329)
RPS27A
Tbio
Novelty:  0.00658124
p_int:  0.999999624
p_ni:  3.76e-7
Score:  0.908
Data Source:  BioPlex,STRINGDB
IGF2
Tbio
Novelty:  0.00021277
p_int:  0.999996623
p_ni:  0.000003377
Data Source:  BioPlex
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.999979969
p_ni:  0.000020031
Score:  0.997
Data Source:  BioPlex,STRINGDB
NMB
Tbio
Novelty:  0.00729571
p_int:  0.99996942
p_ni:  0.00003058
Data Source:  BioPlex
ELAC2
Tbio
Family:  Enzyme
Novelty:  0.01234318
p_int:  0.999779462
p_ni:  0.000220538
Score:  0.669
Data Source:  BioPlex,STRINGDB
INSL6
Tdark
Novelty:  0.06986187
p_int:  0.999458953
p_ni:  0.000541047
Data Source:  BioPlex
AKIRIN2
Tbio
Novelty:  0.04603317
p_int:  0.997991162
p_ni:  0.002008838
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.996079405
p_ni:  0.003920595
Score:  0.968
Data Source:  BioPlex,STRINGDB
LCMT2
Tbio
Family:  Enzyme
Novelty:  0.0388779
p_int:  0.995170292
p_ni:  0.004829704
p_wrong:  3e-9
Score:  0.489
Data Source:  BioPlex,STRINGDB
A1BG
Tbio
Novelty:  0.00508743
p_int:  0.994642469
p_ni:  0.00535753
p_wrong:  1e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
1
1
40.7
reticulocyte measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
40.7
reticulocyte measurement
1
40.7
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UBA domain containing 1
VGNC:4895
746249
Macaque
UBA domain containing 1
711250
Mouse
MGI:1920995
98766
Rat
RGD:1359542
362087
Dog
UBA domain containing 1
VGNC:48042
491256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UBA domain containing 1
Macaque
UBA domain containing 1
Mouse
Rat
Dog
UBA domain containing 1
Publication Statistics
PubMed Score 929.76
PubMed score by year
PubTator Score 54.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title