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Tchem
UBA6
Ubiquitin-like modifier-activating enzyme 6

Protein Summary
Description
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322244
  • ENSP00000313454
  • ENSG00000033178
  • ENST00000420827
  • ENSP00000399234

Symbol
  • MOP4
  • UBE1L2
  • E1-L2
  • MOP-4
  • UBE1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.88
molecular function
0.88
virus perturbation
0.85
transcription factor perturbation
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.2   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.2   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (353)
UBE2L6
Tbio
Novelty:  0.03471633
p_int:  0.999919814
p_ni:  0.000080186
Score:  0.964
Data Source:  BioPlex,STRINGDB
LINC01587
Tdark
Novelty:  0.48128342
p_int:  0.993808596
p_ni:  0.006191404
Data Source:  BioPlex
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.988770598
p_ni:  0.011229397
p_wrong:  5e-9
Data Source:  BioPlex
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.975219598
p_ni:  0.024773128
p_wrong:  0.000007273
Data Source:  BioPlex
CAPN6
Tbio
Novelty:  0.04489237
p_int:  0.974302057
p_ni:  0.025694947
p_wrong:  0.000002996
Score:  0.169
Data Source:  BioPlex,STRINGDB
PLEKHO1
Tbio
Novelty:  0.01658553
p_int:  0.964660167
p_ni:  0.035339362
p_wrong:  4.71e-7
Data Source:  BioPlex
FYTTD1
Tbio
Novelty:  0.04600073
p_int:  0.95028948
p_ni:  0.049710142
p_wrong:  3.78e-7
Score:  0.162
Data Source:  BioPlex,STRINGDB
ALDH3B1
Tbio
Family:  Enzyme
Novelty:  0.03330389
p_int:  0.936657745
p_ni:  0.063341859
p_wrong:  3.96e-7
Score:  0.198
Data Source:  BioPlex,STRINGDB
OR5F1
Tdark
Family:  oGPCR
Novelty:  13
p_int:  0.936211011
p_ni:  0.06378791
p_wrong:  0.000001079
Score:  0.234
Data Source:  BioPlex,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.926517724
p_ni:  0.072093271
p_wrong:  0.001389005
Score:  0.205
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
social interaction measurement
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
social interaction measurement
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like modifier activating enzyme 6
VGNC:7427
461294
Macaque
ubiquitin like modifier activating enzyme 6
711751
Mouse
MGI:1913894
231380
Rat
RGD:1308324
305268
Dog
ubiquitin like modifier activating enzyme 6
VGNC:48040
475160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin like modifier activating enzyme 6
Macaque
ubiquitin like modifier activating enzyme 6
Mouse
Rat
Dog
ubiquitin like modifier activating enzyme 6
Publication Statistics
PubMed Score 19.20
PubMed score by year
PubTator Score 11.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title