Tbio UBA52 Ubiquitin-60S ribosomal protein L40

Protein Summary

Description

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. 60S ribosomal protein L40: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs. Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62987
• P02248
• P02249
• P02250
• P14793
• P62988
• Q29120
• Q6LBL4
• Q6LDU5
• Q8WYN8
• Q91887
• Q91888
• Q9BWD6
• Q9BX98
• Q9UEF2
• Q9UEG1
• Q9UEK8
• Q9UPK7

Gene Name

• UBA52

Ensembl ID

• ENST00000430157
• ENSP00000396910
• ENSG00000221983
• ENST00000442744
• ENSP00000388107
• ENST00000595158
• ENSP00000471622
• ENST00000595683
• ENSP00000470419
• ENST00000596273
• ENSP00000471062
• ENST00000596304
• ENSP00000472264
• ENST00000597451
• ENSP00000473048
• ENST00000598780
• ENSP00000472545
• ENST00000599551
• ENSP00000470507
• ENST00000599595
• ENSP00000471464

Symbol

• UBCEP2
• L40
• CEP52
• RPL40
• HUBCEP52

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
interacting protein	1
small molecule perturbation	1
hub protein	0.88
virus perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Ubiquitin-60s Ribosomal Protein L40

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Ubiquitin-60s Ribosomal Protein L40

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.96   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 280   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.96   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0