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Tbio
UAP1
UDP-N-acetylhexosamine pyrophosphorylase

Protein Summary
Description
Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271469
  • ENSP00000271469
  • ENSG00000117143
  • ENST00000367924
  • ENSP00000356901
  • ENST00000367925
  • ENSP00000356902
  • ENST00000367926
  • ENSP00000356903

Symbol
  • SPAG2
  • AGX
  • AGX1
  • AGX2
  • SPAG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.83
disease perturbation
0.74
transcription factor perturbation
0.74
tissue
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.74   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.74   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0