You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
U2AF2
Splicing factor U2AF 65 kDa subunit

Protein Summary
Description
Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186). U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308924
  • ENSP00000307863
  • ENSG00000063244
  • ENST00000450554
  • ENSP00000388475

Symbol
  • U2AF65
  • U2AF65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.9
transcription factor binding site profile
0.88
hub protein
0.85
protein complex
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.14   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.14   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (442)
U2AF1
Tbio
Novelty:  0.01181981
p_int:  0.999999834
p_ni:  1.66e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
SCAF11
Tdark
Novelty:  0.00802779
p_int:  0.999999456
p_ni:  5.44e-7
Score:  0.818
Data Source:  BioPlex,STRINGDB
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.999999233
p_ni:  7.67e-7
Score:  0.282
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999722393
p_ni:  0.000277607
Score:  0.736
Data Source:  BioPlex,STRINGDB
SRSF12
Tbio
Novelty:  0.34992606
p_int:  0.999574409
p_ni:  0.000425106
p_wrong:  4.85e-7
Score:  0.822
Data Source:  BioPlex,STRINGDB
SRPK1
Tchem
Family:  Kinase
Novelty:  0.01066655
p_int:  0.999531098
p_ni:  0.000468902
Score:  0.871
Data Source:  BioPlex,STRINGDB
GPATCH8
Tdark
Novelty:  0.45717416
p_int:  0.999087867
p_ni:  0.000912133
Score:  0.368
Data Source:  BioPlex,STRINGDB
SRPK2
Tchem
Family:  Kinase
Novelty:  0.03217228
p_int:  0.998950517
p_ni:  0.001049483
Score:  0.789
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.997724474
p_ni:  0.002275526
Score:  0.335
Data Source:  BioPlex,STRINGDB
ACIN1
Tbio
Novelty:  0.01675479
p_int:  0.996845878
p_ni:  0.003154116
p_wrong:  6e-9
Score:  0.486
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
2
3
72.7
insomnia measurement
1
2
0
1.1
56.3
high density lipoprotein cholesterol measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
72.7
insomnia measurement
0
1.1
56.3
high density lipoprotein cholesterol measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
U2 small nuclear RNA auxiliary factor 2
VGNC:2208
456312
Macaque
U2 small nuclear RNA auxiliary factor 2
703269
Mouse
MGI:98886
22185
Rat
RGD:1310690
308335
Dog
U2 small nuclear RNA auxiliary factor 2
VGNC:48032
100687048
Species
Name
OMA
EggNOG
Inparanoid
Chimp
U2 small nuclear RNA auxiliary factor 2
Macaque
U2 small nuclear RNA auxiliary factor 2
Mouse
Rat
Dog
U2 small nuclear RNA auxiliary factor 2
Publication Statistics
PubMed Score 168.14
PubMed score by year
PubTator Score 121.07
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title