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Tbio
TYW5
tRNA wybutosine-synthesizing protein 5

Protein Summary
Description
tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354611
  • ENSP00000346627
  • ENSG00000162971

Symbol
  • C2orf60
  • hTYW5
  • C2orf60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
cellular component
0.84
molecular function
0.73
transcription factor binding site profile
0.69
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
SPATA46
Tdark
Novelty:  0.327066
p_int:  0.999778426
p_ni:  0.000221573
Score:  0.243
Data Source:  BioPlex,STRINGDB
USE1
Tbio
Novelty:  0.00904756
p_int:  0.999708921
p_ni:  0.000291079
Score:  0.663
Data Source:  BioPlex,STRINGDB
METTL6
Tbio
Family:  Enzyme
Novelty:  0.43606491
p_int:  0.999304081
p_ni:  0.000695919
Score:  0.205
Data Source:  BioPlex,STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.998507026
p_ni:  0.001492961
p_wrong:  1.3e-8
Data Source:  BioPlex
SUN1
Tbio
Novelty:  0.00931817
p_int:  0.998259188
p_ni:  0.001740812
Data Source:  BioPlex
STX7
Tbio
Novelty:  0.03109969
p_int:  0.997457285
p_ni:  0.002542709
p_wrong:  6e-9
Data Source:  BioPlex
NSA2
Tbio
Novelty:  0.04542275
p_int:  0.997146328
p_ni:  0.002853672
Score:  0.159
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.968621439
p_ni:  0.031377216
p_wrong:  0.000001345
Data Source:  BioPlex
TRMT12
Tbio
Family:  Enzyme
Novelty:  0.12417204
Score:  0.874
Data Source:  STRINGDB
TYW1
Tbio
Family:  Enzyme
Novelty:  0.05117274
Score:  0.829
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Synthesis of wybutosine at G37 of tRNA(Phe)
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Synthesis of wybutosine at G37 of tRNA(Phe)
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
5
2
1
1.1
84.2
1
1
0
1.1
56.7
LDL cholesterol:HDL cholesterol ratio
1
1
1
43.1
body weight
1
1
1
19.6
waist-hip ratio
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
1
1.1
84.2
0
1.1
56.7
LDL cholesterol:HDL cholesterol ratio
1
43.1
body weight
1
19.6
waist-hip ratio
1
8.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA-yW synthesizing protein 5
VGNC:2899
745971
Mouse
MGI:1915986
68736
Rat
RGD:1311269
301419
Dog
tRNA-yW synthesizing protein 5
VGNC:48031
478861
Horse
tRNA-yW synthesizing protein 5
VGNC:24695
100055324
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA-yW synthesizing protein 5
Mouse
Rat
Dog
tRNA-yW synthesizing protein 5
Horse
tRNA-yW synthesizing protein 5
Publication Statistics
PubMed Score 7.68
PubMed score by year
PubTator Score 2.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title