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Tdark
TYW3
tRNA wybutosine-synthesizing protein 3 homolog

Protein Summary
Description
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370867
  • ENSP00000359904
  • ENSG00000162623
  • ENST00000457880
  • ENSP00000407025

Symbol
  • C1orf171
  • C1orf171
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor
0.68
transcription factor binding site profile
0.66
transcription factor perturbation
0.61
microRNA
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.17   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.17   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
ZKSCAN4
Tbio
Family:  TF
Novelty:  0.33154485
p_int:  1
Data Source:  BioPlex
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.999999601
p_ni:  3.99e-7
Data Source:  BioPlex
KIF2A
Tbio
Novelty:  0.01463006
p_int:  0.9999996
p_ni:  4e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
MTRF1
Tbio
Family:  Enzyme
Novelty:  0.11037387
p_int:  0.999938974
p_ni:  0.000060971
p_wrong:  5.4e-8
Data Source:  BioPlex
TINAG
Tbio
Novelty:  0.04582927
p_int:  0.999884888
p_ni:  0.000115112
Data Source:  BioPlex
GCLC
Tchem
Family:  Enzyme
Novelty:  0.00217206
p_int:  0.999695006
p_ni:  0.000304994
Score:  0.187
Data Source:  BioPlex,STRINGDB
SORL1
Tbio
Novelty:  0.00380895
p_int:  0.999633184
p_ni:  0.000366816
Data Source:  BioPlex
ZKSCAN3
Tbio
Family:  TF
Novelty:  0.06833314
p_int:  0.998246183
p_ni:  0.000631147
p_wrong:  0.00112267
Score:  0.294
Data Source:  BioPlex,STRINGDB
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.996318303
p_ni:  0.003681697
Data Source:  BioPlex
DDHD1
Tbio
Family:  Enzyme
Novelty:  0.05209502
p_int:  0.995775041
p_ni:  0.004221257
p_wrong:  0.000003702
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Synthesis of wybutosine at G37 of tRNA(Phe)
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Synthesis of wybutosine at G37 of tRNA(Phe)
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
78.3
educational attainment
1
3
3
65.8
heel bone mineral density
1
1
1
38.2
resistin measurement
1
1
1
34.6
amyotrophic lateral sclerosis
1
1
0
1.6
31.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
78.3
educational attainment
3
65.8
heel bone mineral density
1
38.2
resistin measurement
1
34.6
amyotrophic lateral sclerosis
0
1.6
31.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA-yW synthesizing protein 3 homolog
VGNC:9904
745288
Macaque
tRNA-yW synthesizing protein 3 homolog
704515
Mouse
MGI:2445040
209584
Rat
RGD:1559623
499731
Dog
tRNA-yW synthesizing protein 3 homolog
VGNC:48030
479986
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA-yW synthesizing protein 3 homolog
Macaque
tRNA-yW synthesizing protein 3 homolog
Mouse
Rat
Dog
tRNA-yW synthesizing protein 3 homolog
Publication Statistics
PubMed Score 5.17
PubMed score by year
PubTator Score 2.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title