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Tdark
TYW1B
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

Protein Summary
Description
Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). Wybutosine is a hypermodified guanosine found in phenylalanine tRNA. Wybutosine functions to stabilize codon-anticodon interactions during ribosome decoding and therefore supports the maintenance of the reading frame. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. The human genome contains two closely related genes that putatively function in wybutosine synthesis. The open reading frame of this locus is disrupted in some individuals. Thus, this locus appears to be an evolving pseudogene, but may still be functional in some members of the population. [provided by RefSeq, A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000620995
  • ENSP00000482502
  • ENSG00000277149

Symbol
  • RSAFD2
  • RSAFD2
  • LINC00069
  • NCRNA00069
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.81
cellular component
0.75
trait
0.61
tissue sample
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.17   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.17   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.999107412
p_ni:  0.000892588
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.99630472
p_ni:  0.003693892
p_wrong:  0.000001388
Data Source:  BioPlex
RANBP6
Tdark
Novelty:  0.75714796
p_int:  0.995902228
p_ni:  0.004047112
p_wrong:  0.00005066
Score:  0.253
Data Source:  BioPlex,STRINGDB
SPACA1
Tbio
Novelty:  0.07415851
p_int:  0.994932023
p_ni:  0.004853261
p_wrong:  0.000214716
Data Source:  BioPlex
ARL15
Tbio
Family:  Enzyme
Novelty:  0.09327102
p_int:  0.994823849
p_ni:  0.005070307
p_wrong:  0.000105844
Score:  0.167
Data Source:  BioPlex,STRINGDB
KLRC4
Tbio
Novelty:  0.16922525
p_int:  0.984990977
p_ni:  0.014806072
p_wrong:  0.000202951
Data Source:  BioPlex
ENTPD4
Tbio
Family:  Enzyme
Novelty:  0.11023026
p_int:  0.98224343
p_ni:  0.017568669
p_wrong:  0.000187902
Score:  0.204
Data Source:  BioPlex,STRINGDB
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.969982571
p_ni:  0.02957926
p_wrong:  0.000438169
Data Source:  BioPlex
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
p_int:  0.917361222
p_ni:  0.082498906
p_wrong:  0.000139872
Data Source:  BioPlex
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.889601732
p_ni:  0.008459463
p_wrong:  0.101938805
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
tRNA modification; wybutosine-tRNA(Phe) biosynthesis.
Name
Explore in Pharos
Explore in Source
tRNA modification; wybutosine-tRNA(Phe) biosynthesis.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
4
5
8
7.9
96.6
serum gamma-glutamyl transferase measurement
1
2
2
71.1
mathematical ability
3
1
3
52
self reported educational attainment
2
2
2
43.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
8
7.9
96.6
serum gamma-glutamyl transferase measurement
2
71.1
mathematical ability
3
52
self reported educational attainment
2
43.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2141161
100929
Rat
RGD:1310420
304423
Cow
tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
533109
Opossum
tRNA-yW synthesizing protein 1 homolog
100010958
Xenopus
tRNA-yW synthesizing protein 1 homolog
XB-GENE-5955779
100124832
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Opossum
tRNA-yW synthesizing protein 1 homolog
Xenopus
tRNA-yW synthesizing protein 1 homolog
Publication Statistics
PubMed Score 1.17
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title