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Tbio
TYSND1
Peroxisomal leader peptide-processing protease

Protein Summary
Description
Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids. This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287078
  • ENSP00000287078
  • ENSG00000156521
  • ENST00000335494
  • ENSP00000335673

Symbol
  • NET41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
transcription factor perturbation
0.8
disease perturbation
0.79
transcription factor binding site profile
0.65
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
JOSD2
Tbio
Novelty:  0.27109362
p_int:  0.99436847
p_ni:  0.005631394
p_wrong:  1.36e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
XXYLT1
Tbio
Family:  Enzyme
Novelty:  0.16837376
p_int:  0.994311485
p_ni:  0.005688515
Data Source:  BioPlex
TEKT3
Tbio
Novelty:  0.06646482
p_int:  0.930594768
p_ni:  0.069405232
Score:  0.345
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.911765372
p_ni:  0.088234628
Score:  0.238
Data Source:  BioPlex,STRINGDB
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
p_int:  0.85422518
p_ni:  0.14577482
Score:  0.232
Data Source:  BioPlex,STRINGDB
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.805350796
p_ni:  0.194649204
Score:  0.19
Data Source:  BioPlex,STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
Score:  0.983
Data Source:  Reactome,STRINGDB
ACAA1
Tbio
Family:  Enzyme
Novelty:  0.00710465
Score:  0.979
Data Source:  Reactome,STRINGDB
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
Score:  0.974
Data Source:  STRINGDB
PEX14
Tbio
Novelty:  0.0210557
Score:  0.964
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Peroxisomal protein import (R-HSA-9033241)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Peroxisomal protein import
Reactome
Protein localization
Reactome
TYSND1 cleaves peroxisomal proteins
Name
Explore in Pharos
Explore in Source
Peroxisomal protein import
Protein localization
TYSND1 cleaves peroxisomal proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
38.8
eyelid sagging measurement
1
1
0
4
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
38.8
eyelid sagging measurement
0
4
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trypsin domain containing 1
VGNC:5869
746962
Macaque
trypsin domain containing 1
100425207
Mouse
MGI:1919017
71767
Rat
RGD:1307354
365571
Horse
trypsin domain containing 1
VGNC:51834
100072712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trypsin domain containing 1
Macaque
trypsin domain containing 1
Mouse
Rat
Horse
trypsin domain containing 1
Publication Statistics
PubMed Score 6.20
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title