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Tchem
TYRO3
Tyrosine-protein kinase receptor TYRO3

Protein Summary
Description
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppre ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263798
  • ENSP00000263798
  • ENSG00000092445

Symbol
  • BYK
  • DTK
  • RSE
  • SKY
  • TIF
  • BYK
  • Dtk
  • RSE
  • Rek
  • Sky
  • Tif
  • Etk-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
PubMedID
0.9
biological process
0.89
transcription factor binding site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.72   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 644   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.72   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 644   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 57
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (48)
CHRNB3
Tchem
Family:  IC
Novelty:  0.031456
p_int:  0.999999978
p_ni:  2.1e-8
Score:  0.569
Data Source:  BioPlex,STRINGDB
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.999999296
p_ni:  7.03e-7
Score:  0.167
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.999997449
p_ni:  0.000002541
p_wrong:  1e-8
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999983894
p_ni:  0.000016032
p_wrong:  7.5e-8
Data Source:  BioPlex
GAS6
Tbio
Novelty:  0.00297606
Score:  0.912
Data Source:  STRINGDB
PROS1
Tbio
Novelty:  0.00275184
Score:  0.816
Data Source:  STRINGDB
GP2
Tbio
Novelty:  0.00126542
Score:  0.744
Data Source:  STRINGDB
SOCS1
Tbio
Novelty:  0.00131368
Score:  0.664
Data Source:  STRINGDB
NPC1
Tchem
Novelty:  0.00155015
Score:  0.637
Data Source:  STRINGDB
CLEC4G
Tbio
Novelty:  0.04409132
Score:  0.63
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
LncRNA involvement in canonical Wnt signaling and colorectal cancer
Name
Explore in Pharos
Explore in Source
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
LncRNA involvement in canonical Wnt signaling and colorectal cancer
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
2
2
78.9
lymphocyte percentage of leukocytes
2
2
2
74.6
high density lipoprotein cholesterol measurement
2
2
2
73.5
childhood onset asthma
1
1
0
1.1
70.2
eosinophil percentage of leukocytes
1
1
1
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
78.9
lymphocyte percentage of leukocytes
2
74.6
high density lipoprotein cholesterol measurement
2
73.5
childhood onset asthma
0
1.1
70.2
eosinophil percentage of leukocytes
1
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TYRO3 protein tyrosine kinase
VGNC:1584
453352
Macaque
TYRO3 protein tyrosine kinase
710902
Mouse
MGI:104294
22174
Rat
RGD:3923
25232
Dog
TYRO3 protein tyrosine kinase
VGNC:48027
487509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TYRO3 protein tyrosine kinase
Macaque
TYRO3 protein tyrosine kinase
Mouse
Rat
Dog
TYRO3 protein tyrosine kinase
Publication Statistics
PubMed Score 387.72
PubMed score by year
PubTator Score 164.45
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title