Tclin TYMS Thymidylate synthase

Protein Summary

Description

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P04818
• Q8WYK3
• Q8WYK4
• TS

Gene Name

• TYMS

Ensembl ID

• ENST00000323224
• ENSP00000314727
• ENSG00000176890
• ENST00000323250
• ENSP00000314902
• ENST00000323274
• ENSP00000315644

Symbol

• TS
• TS
• TMS
• HST422

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
co-expressed gene	0.97
molecular function	0.95
disease	0.94
kinase perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Thymidylate Synthase

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Thymidylate Synthase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1041.94   (req: < 5)

Gene RIFs: 412   (req: <= 3)

Antibodies: 1067   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1041.94   (req: >= 5)

Gene RIFs: 412   (req: > 3)

Antibodies: 1067   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 306

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6