Protein Summary
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
- ENST00000252029
- ENSP00000252029
- ENSG00000025708
- ENST00000395678
- ENSP00000379036
- ENST00000395680
- ENSP00000379037
- ENST00000395681
- ENSP00000379038
- ECGF1
- TP
- ECGF
- ECGF1
- MNGIE
- MEDPS1
- MTDPS1
- PDECGF
- hPD-ECGF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.85 | ||
protein domain | 0.85 | ||
disease | 0.71 | ||
tissue sample | 0.65 | ||
biological process | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 616.39 (req: < 5)
Gene RIFs: 121 (req: <= 3)
Antibodies: 755 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 616.39 (req: >= 5)
Gene RIFs: 121 (req: > 3)
Antibodies: 755 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 26
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (26)
Protein-Protein Interactions (102)
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.999897598
p_ni: 0.000102402
Score: 0.205
Data Source: BioPlex,STRINGDB
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999848319
p_ni: 0.000151681
Data Source: BioPlex
GPATCH2L
Novelty: 1.68490464
p_int: 0.999818257
p_ni: 0.000181743
Score: 0.173
Data Source: BioPlex,STRINGDB
SUSD3
Novelty: 0.43699506
p_int: 0.994229778
p_ni: 0.005761562
p_wrong: 0.00000866
Score: 0.18
Data Source: BioPlex,STRINGDB
SINHCAF
Novelty: 0.18692832
p_int: 0.993710714
p_ni: 0.006288702
p_wrong: 5.84e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (22)
Reactome (6)
KEGG (4)
PathwayCommons (6)
UniProt (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleobase catabolism | ||||
Reactome | Nucleotide salvage | ||||
Reactome | Pyrimidine catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleobase catabolism | ||||
Nucleotide salvage | ||||
Pyrimidine catabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (6)
Components (1)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 5 | 7 | 8 | 99 | |||||
mean reticulocyte volume | 1 | 4 | 4 | 97.6 | |||||
red blood cell distribution width | 4 | 4 | 4 | 95.6 | |||||
mean corpuscular hemoglobin | 3 | 3 | 3 | 94.6 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 91.5 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 8 | 99 | |||||
mean reticulocyte volume | 4 | 97.6 | |||||
red blood cell distribution width | 4 | 95.6 | |||||
mean corpuscular hemoglobin | 3 | 94.6 | |||||
mean corpuscular hemoglobin concentration | 2 | 91.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thymidine phosphorylase | VGNC:5982 | 458941 | |||||
Macaque | thymidine phosphorylase | 716161 | ||||||
Mouse | MGI:1920212 | 72962 | ||||||
Rat | RGD:1305756 | 315219 | ||||||
Horse | thymidine phosphorylase | VGNC:24688 | 100146854 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thymidine phosphorylase | |||||
Macaque | thymidine phosphorylase | |||||
Mouse | ||||||
Rat | ||||||
Horse | thymidine phosphorylase | |||||
Publication Statistics
PubMed Score 616.39
PubMed score by year
PubTator Score 538.48
PubTator score by year
Related Publications
Text Mined References (156)
GeneRif Annotations (121)
Items per page:
0 of 0
PMID | Year | Title |
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