Tclin TYMP Thymidine phosphorylase

Protein Summary

Description

May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• P19971
• A8MW15
• H9KVA0
• Q13390
• Q8WVB7
• TP

Gene Name

• TYMP

Ensembl ID

• ENST00000252029
• ENSP00000252029
• ENSG00000025708
• ENST00000395678
• ENSP00000379036
• ENST00000395680
• ENSP00000379037
• ENST00000395681
• ENSP00000379038

Symbol

• ECGF1
• TP
• ECGF
• ECGF1
• MNGIE
• MEDPS1
• MTDPS1
• PDECGF
• hPD-ECGF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.85
protein domain	0.85
disease	0.71
tissue sample	0.65
biological process	0.64

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Thymidine Phosphorylase

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Thymidine Phosphorylase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 699   (req: < 5)

Gene RIFs: 130   (req: <= 3)

Antibodies: 755   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 699   (req: >= 5)

Gene RIFs: 130   (req: > 3)

Antibodies: 755   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1