Tbio TXNRD2 Thioredoxin reductase 2, mitochondrial

Protein Summary

Description

Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017]

Uniprot Accession IDs

• Q9NNW7
• O95840
• Q96IJ2
• Q9H2Z5
• Q9NZV3
• Q9NZV4
• Q9P2Y0
• Q9P2Y1
• Q9UQU8

Gene Name

• TXNRD2

Ensembl ID

• ENST00000400521
• ENSP00000383365
• ENSG00000184470
• ENST00000542719
• ENSP00000485128

Symbol

• KIAA1652
• TRXR2
• TR
• TR3
• SELZ
• GCCD5
• TRXR2
• TR-BETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
protein domain	0.92
molecular function	0.9
transcription factor perturbation	0.84
disease perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Thioredoxin Reductase 2, Mitochondrial

Protein / Oxidoreductase / Oxidase / Thioredoxin Reductase 2, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Thioredoxin Reductase 2, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Thioredoxin Reductase 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.19   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 537.19   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0