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Tbio
TXNL4A
Thioredoxin-like protein 4A

Protein Summary
Description
Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269601
  • ENSP00000269601
  • ENSG00000141759

Symbol
  • DIM1
  • TXNL4
  • BMKS
  • DIB1
  • DIM1
  • TXNL4
  • SNRNP15
  • U5-15kD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor binding site profile
0.84
disease perturbation
0.83
tissue sample
0.76
histone modification site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.7   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.7   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (246)
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.999159693
p_ni:  0.000840307
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRPF6
Tbio
Novelty:  0.02818008
p_int:  0.991949496
p_ni:  0.008050504
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRNP40
Tbio
Novelty:  0.16791896
p_int:  0.979627132
p_ni:  0.020372868
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.973726621
p_ni:  0.026273379
p_wrong:  1e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.970883106
p_ni:  0.029116894
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.966099145
p_ni:  0.033900855
Data Source:  BioPlex
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.946544663
p_ni:  0.053455337
Score:  0.997
Data Source:  BioPlex,STRINGDB
DDX23
Tbio
Family:  Enzyme
Novelty:  0.03592096
p_int:  0.882069704
p_ni:  0.117930296
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.780198635
p_ni:  0.219801299
p_wrong:  6.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.75301514
p_ni:  0.246984845
p_wrong:  1.5e-8
Score:  0.715
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Metabolism of RNA (R-HSA-8953854)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
47.7
self reported educational attainment
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
47.7
self reported educational attainment
1
39.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin like 4A
VGNC:13296
455490
Macaque
thioredoxin like 4A
698969
Mouse
MGI:1351613
27366
Dog
thioredoxin like 4A
VGNC:48019
476156
Horse
thioredoxin like 4A
VGNC:24684
100052390
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin like 4A
Macaque
thioredoxin like 4A
Mouse
Dog
thioredoxin like 4A
Horse
thioredoxin like 4A
Publication Statistics
PubMed Score 20.70
PubMed score by year
PubTator Score 18.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title