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Tbio
TXNL1
Thioredoxin-like protein 1

Protein Summary
Description
Active thioredoxin with a redox potential of about -250 mV.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217515
  • ENSP00000217515
  • ENSG00000091164
  • ENST00000590954
  • ENSP00000464918

Symbol
  • TRP32
  • TXL
  • TXNL
  • Txl
  • TXNL
  • TRP32
  • TXL-1
  • HEL-S-114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.99
kinase perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.97   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.97   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (135)
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.983231138
p_ni:  0.016768862
Data Source:  BioPlex
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.763035444
p_ni:  0.236964556
Data Source:  BioPlex
PSMD14
Tchem
Family:  Enzyme
Novelty:  0.01019285
Score:  0.967
Data Source:  STRINGDB
TXNDC17
Tbio
Novelty:  0.0142537
Score:  0.929
Data Source:  STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
Score:  0.898
Data Source:  STRINGDB
USP14
Tchem
Family:  Enzyme
Novelty:  0.00947074
Score:  0.891
Data Source:  STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
Score:  0.884
Data Source:  STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
Score:  0.883
Data Source:  STRINGDB
PSMC1
Tbio
Family:  Enzyme
Novelty:  0.04631888
Score:  0.86
Data Source:  STRINGDB
PSMD3
Tbio
Family:  Enzyme
Novelty:  0.03106272
Score:  0.829
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
11.2
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin like 1
VGNC:5219
455433
Macaque
thioredoxin like 1
695194
Mouse
MGI:1860078
53382
Rat
RGD:621717
140922
Dog
thioredoxin like 1
VGNC:48018
483970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin like 1
Macaque
thioredoxin like 1
Mouse
Rat
Dog
thioredoxin like 1
Publication Statistics
PubMed Score 79.97
PubMed score by year
PubTator Score 51.93
PubTator score by year
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Related Publications
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PMID
Year
Title