You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TXNDC15
Thioredoxin domain-containing protein 15

Protein Summary
Description
This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358387
  • ENSP00000351157
  • ENSG00000113621

Symbol
  • C5orf14
  • BUG
  • UNQ335
  • C5orf14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.79
cell type or tissue
0.69
tissue sample
0.66
transcription factor binding site profile
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
TAPT1
Tbio
Novelty:  0.12057711
p_int:  0.999995996
p_ni:  0.000003889
p_wrong:  1.15e-7
Score:  0.207
Data Source:  BioPlex,STRINGDB
MARCH6
Tbio
Family:  Enzyme
Novelty:  0.01818691
p_int:  0.999993174
p_ni:  0.000006724
p_wrong:  1.02e-7
Score:  0.549
Data Source:  BioPlex,STRINGDB
PIGN
Tbio
Family:  Enzyme
Novelty:  0.02210783
p_int:  0.999401393
p_ni:  0.000594624
p_wrong:  0.000003983
Score:  0.527
Data Source:  BioPlex,STRINGDB
NEK4
Tchem
Family:  Kinase
Novelty:  0.05805595
p_int:  0.998778043
p_ni:  0.001221957
Score:  0.237
Data Source:  BioPlex,STRINGDB
UBE2W
Tbio
Novelty:  0.07255713
p_int:  0.998729398
p_ni:  0.001269949
p_wrong:  6.54e-7
Data Source:  BioPlex
GRAMD2B
Tdark
Novelty:  0.55744753
p_int:  0.998031544
p_ni:  0.001968455
Data Source:  BioPlex
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.99762375
p_ni:  0.00237625
Data Source:  BioPlex
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.996312768
p_ni:  0.003687232
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.996106084
p_ni:  0.003893916
Data Source:  BioPlex
MCUB
Tbio
Novelty:  0.0486243
p_int:  0.996035418
p_ni:  0.003956693
p_wrong:  0.000007889
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Joubert Syndrome
Name
Explore in Pharos
Explore in Source
Genes related to primary cilium development (based on CRISPR)
Genes related to primary cilium development (based on CRISPR)
Joubert Syndrome
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin domain containing 15
VGNC:4216
745182
Mouse
MGI:1916922
69672
Rat
RGD:1304696
307180
Dog
thioredoxin domain containing 15
VGNC:48012
609963
Horse
thioredoxin domain containing 15
VGNC:24678
100072729
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin domain containing 15
Mouse
Rat
Dog
thioredoxin domain containing 15
Horse
thioredoxin domain containing 15
Publication Statistics
PubMed Score 4.86
PubMed score by year
PubTator Score 41.67
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title