Pharos : Target Details

Tbio

Protein Summary

Description

Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.

Uniprot Accession IDs

Gene Name

TXLNB

Ensembl ID

ENST00000358430
ENSP00000351206
ENSG00000164440

Symbol

C6orf198
MDP77
MDP77
LST001
C6orf198
dJ522B19.2

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.89

gene perturbation	0.68

microRNA	0.68

histone modification site profile	0.63

tissue sample	0.6

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.64 (req: < 5)

View Publications

Gene RIFs: 3 (req: <= 3)

View Gene RIFs

Antibodies: 123 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.64 (req: >= 5)

Gene RIFs: 3 (req: > 3)

Antibodies: 123 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

See Interactions on String-DB

TXLNG

Tbio

Novelty: 0.08274423

p_int: 0.999999989

p_ni: 1.1e-8

Score: 0.866

Data Source: BioPlex,STRINGDB

DTNBP1

Tbio

Novelty: 0.00341619

p_int: 0.999999971

p_ni: 2.9e-8

Score: 0.536

Data Source: BioPlex,STRINGDB

CEP135

Tbio

Novelty: 0.03507768

p_int: 0.99999997

p_ni: 1.6e-8

p_wrong: 1.4e-8

Score: 0.188

Data Source: BioPlex,STRINGDB

KIF18B

Tbio

Novelty: 0.06496349

p_int: 0.999999038

p_ni: 9.62e-7

Score: 0.161

Data Source: BioPlex,STRINGDB

TXLNA

Tbio

Novelty: 0.02549959

p_int: 0.99999707

p_ni: 5.35e-7

p_wrong: 0.000002396

Score: 0.868

Data Source: BioPlex,STRINGDB

ATG7

Tchem

Novelty: 0.00120728

p_int: 0.999995512

p_ni: 0.000004488

Score: 0.16

Data Source: BioPlex,STRINGDB

C1orf122

Tdark

Novelty: 11.73333333

p_int: 0.999985125

p_ni: 0.000014737

p_wrong: 1.39e-7

Score: 0.741

Data Source: BioPlex,STRINGDB

CEP63

Tbio

Novelty: 0.08869992

p_int: 0.999971514

p_ni: 0.000028371

p_wrong: 1.15e-7

Score: 0.39

Data Source: BioPlex,STRINGDB

MED4

Tbio

Family: Enzyme

Novelty: 0.01200585

p_int: 0.999933765

p_ni: 0.000066235

Score: 0.183

Data Source: BioPlex,STRINGDB

SPDL1

Tbio

Novelty: 0.01399644

p_int: 0.999741033

p_ni: 0.000258967

Score: 0.177

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (2)

Functions (1)

Components (1)

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Items per page:

1 – 1 of 1

GO Term	Evidence	Assigned by
syntaxin binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (5)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
serum non-albumin protein measurement	EFO_0004568	2	3	3	66.8

heel bone mineral density	EFO_0009270	2	2	2	59.5

mean reticulocyte volume	EFO_0010701	1	1	1	53.3

mean corpuscular volume	EFO_0004526	1	1	1	42.3

albumin:globulin ratio measurement	EFO_0005128	1	1	1	8

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
serum non-albumin protein measurement	EFO_0004568	3	66.8

heel bone mineral density	EFO_0009270	2	59.5

mean reticulocyte volume	EFO_0010701	1	53.3

mean corpuscular volume	EFO_0004526	1	42.3

albumin:globulin ratio measurement	EFO_0005128	1	8

Beta Count

Odds Ratio

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UniProt Keyword

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GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Chimp	taxilin beta	VGNC:3779	463155

Macaque	taxilin beta		707955

Mouse	taxilin beta	MGI:2671945	378431

Rat	taxilin beta	RGD:1307979	308622

Dog	taxilin beta	VGNC:48007	476224

Species	Name	OMA	EggNOG	Inparanoid
Chimp	taxilin beta

Macaque	taxilin beta

Mouse	taxilin beta

Rat	taxilin beta

Dog	taxilin beta

Publication Statistics

PubMed Score 8.64

PubMed score by year

PubTator Score 2.83

PubTator score by year

Related Publications

Text Mined References (15)

GeneRif Annotations (3)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Coiled coil

Complete proteome

Phosphoprotein

Polymorphism

Reference proteome