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Tbio
TWSG1
Twisted gastrulation protein homolog 1

Protein Summary
Description
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262120
  • ENSP00000262120
  • ENSG00000128791
  • ENST00000583147
  • ENSP00000463331

Symbol
  • TSG
  • TSG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
virus perturbation
0.85
kinase perturbation
0.84
transcription factor binding site profile
0.81
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 384.27   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 384.27   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
BMP4
Tchem
Novelty:  0.00047387
p_int:  0.997020278
p_ni:  0.002955861
p_wrong:  0.000023861
Score:  0.894
Data Source:  BioPlex,STRINGDB
C8A
Tbio
Novelty:  0.00429321
p_int:  0.923497102
p_ni:  0.076055219
p_wrong:  0.000447678
Data Source:  BioPlex
CHRD
Tbio
Novelty:  0.00347659
Score:  0.892
Data Source:  STRINGDB
BMP2
Tbio
Novelty:  0.00016974
Score:  0.801
Data Source:  STRINGDB
BMP5
Tbio
Novelty:  0.00866987
Score:  0.768
Data Source:  STRINGDB
BMP1
Tchem
Novelty:  0.00299518
Score:  0.759
Data Source:  STRINGDB
BMPER
Tbio
Novelty:  0.00687606
Score:  0.743
Data Source:  STRINGDB
CHRDL2
Tbio
Novelty:  0.02014764
Score:  0.72
Data Source:  STRINGDB
BMP6
Tbio
Novelty:  0.00197133
Score:  0.708
Data Source:  STRINGDB
BMP7
Tbio
Novelty:  0.00049424
Score:  0.685
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
59.8
gut microbiome measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
59.8
gut microbiome measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
twisted gastrulation BMP signaling modulator 1
VGNC:5218
455294
Mouse
MGI:2137520
65960
Rat
RGD:1311215
363294
Dog
twisted gastrulation BMP signaling modulator 1
VGNC:48004
490546
Horse
twisted gastrulation BMP signaling modulator 1
VGNC:24671
100054712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
twisted gastrulation BMP signaling modulator 1
Mouse
Rat
Dog
twisted gastrulation BMP signaling modulator 1
Horse
twisted gastrulation BMP signaling modulator 1
Publication Statistics
PubMed Score 384.27
PubMed score by year
PubTator Score 257.67
PubTator score by year
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Related Publications
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PMID
Year
Title