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Tbio
TWIST2
Twist-related protein 2

Protein Summary
Description
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000448943
  • ENSP00000405176
  • ENSG00000233608
  • ENST00000612363
  • ENSP00000482581

Symbol
  • BHLHA39
  • DERMO1
  • AMS
  • FFDD3
  • BBRSAY
  • DERMO1
  • SETLSS
  • bHLHa39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.84
PubMedID
0.73
histone modification site profile
0.65
cell type or tissue
0.61
molecular function
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.12   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.12   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0