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Tbio
TWIST1
Twist-related protein 1

Protein Summary
Description
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity). This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242261
  • ENSP00000242261
  • ENSG00000122691

Symbol
  • BHLHA38
  • TWIST
  • CRS
  • CSO
  • SCS
  • ACS3
  • CRS1
  • BPES2
  • BPES3
  • SWCOS
  • TWIST
  • bHLHa38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.86
phenotype
0.82
kinase
0.81
biological term
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1129.11   (req: < 5)
Gene RIFs: 506   (req: <= 3)
Antibodies: 570   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1129.11   (req: >= 5)
Gene RIFs: 506   (req: > 3)
Antibodies: 570   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (239)
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.999999938
p_ni:  4e-9
p_wrong:  5.8e-8
Score:  0.734
Data Source:  BioPlex,STRINGDB
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.999997125
p_ni:  8e-8
p_wrong:  0.000002795
Score:  0.216
Data Source:  BioPlex,STRINGDB
PPARGC1A
Tbio
Novelty:  0.0003625
Score:  0.983
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.974
Data Source:  STRINGDB
P42771
Tbio
Family:  Enzyme
Novelty:  0.00014147
Score:  0.966
Data Source:  STRINGDB
Q8N726
Tbio
Novelty:  0.00014147
Score:  0.966
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.962
Data Source:  STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.923
Data Source:  STRINGDB
SNAI1
Tbio
Family:  TF
Novelty:  0.00040495
Score:  0.923
Data Source:  STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.921
Data Source:  STRINGDB
Pathways (21)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Interleukin-4 and Interleukin-13 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (63)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
large artery stroke
7
3
0
1.2
93.5
pulse pressure measurement
4
2
4
93.2
balding measurement
1
5
5
91.9
stroke
2
2
0
1.4
88.9
body height
1
2
2
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
large artery stroke
0
1.2
93.5
pulse pressure measurement
4
93.2
balding measurement
5
91.9
stroke
0
1.4
88.9
body height
2
75.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
twist family bHLH transcription factor 1
450135
Mouse
MGI:98872
22160
Rat
RGD:621455
85489
Cow
twist family bHLH transcription factor 1
VGNC:36525
782170
Anole lizard
twist family bHLH transcription factor 1
100379171
Species
Name
OMA
EggNOG
Inparanoid
Chimp
twist family bHLH transcription factor 1
Mouse
Rat
Cow
twist family bHLH transcription factor 1
Anole lizard
twist family bHLH transcription factor 1
Publication Statistics
PubMed Score 1129.11
PubMed score by year
PubTator Score 848.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title