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Tbio
TUT1
Speckle targeted PIP5K1A-regulated poly(A) polymerase

Protein Summary
Description
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation. This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransfe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000476907
  • ENSP00000419607
  • ENSG00000149016

Symbol
  • RBM21
  • PAPD2
  • RBM21
  • TENT1
  • URLC6
  • TUTase
  • STARPAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor binding site profile
0.97
kinase perturbation
0.95
cell type or tissue
0.77
transcription factor
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.05   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.05   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999999978
p_ni:  2.2e-8
Score:  0.843
Data Source:  BioPlex,STRINGDB
SART3
Tbio
Novelty:  0.02353492
p_int:  0.99999995
p_ni:  5e-8
Score:  0.753
Data Source:  BioPlex,STRINGDB
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.999998684
p_ni:  0.000001316
Score:  0.85
Data Source:  BioPlex,STRINGDB
LSM5
Tbio
Novelty:  0.12669584
p_int:  0.999998033
p_ni:  0.000001967
Score:  0.711
Data Source:  BioPlex,STRINGDB
LSM7
Tbio
Novelty:  0.09112723
p_int:  0.999996142
p_ni:  0.000003858
Data Source:  BioPlex
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999994905
p_ni:  0.000005095
Score:  0.713
Data Source:  BioPlex,STRINGDB
PRPF4
Tchem
Novelty:  0.08229072
p_int:  0.999993068
p_ni:  0.000006928
p_wrong:  4e-9
Score:  0.857
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999972603
p_ni:  0.000027397
Score:  0.559
Data Source:  BioPlex,STRINGDB
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.999968166
p_ni:  0.000031827
p_wrong:  7e-9
Data Source:  BioPlex
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999922004
p_ni:  0.000077995
p_wrong:  1e-9
Score:  0.671
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
11
12
96
waist-hip ratio
2
7
8
95.6
waist circumference
1
4
4
92.1
BMI-adjusted waist circumference
1
4
4
90.4
forced expiratory volume
2
2
2
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
96
waist-hip ratio
8
95.6
waist circumference
4
92.1
BMI-adjusted waist circumference
4
90.4
forced expiratory volume
2
89.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
terminal uridylyl transferase 1, U6 snRNA-specific
451254
Macaque
terminal uridylyl transferase 1, U6 snRNA-specific
722271
Mouse
MGI:1917294
70044
Rat
RGD:1561043
499314
Dog
terminal uridylyl transferase 1, U6 snRNA-specific
VGNC:52059
476058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
terminal uridylyl transferase 1, U6 snRNA-specific
Macaque
terminal uridylyl transferase 1, U6 snRNA-specific
Mouse
Rat
Dog
terminal uridylyl transferase 1, U6 snRNA-specific
Publication Statistics
PubMed Score 76.05
PubMed score by year
PubTator Score 24.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title