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Tbio
TUSC3
Tumor suppressor candidate 3

Protein Summary
Description
Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Magnesium transporter. This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382020
  • ENSP00000371450
  • ENSG00000104723
  • ENST00000503731
  • ENSP00000424544

Symbol
  • N33
  • M33
  • N33
  • MRT7
  • MRT22
  • MagT2
  • OST3A
  • D8S1992
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor perturbation
0.84
cellular component
0.75
pathway
0.74
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.67   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.67   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
p_int:  0.999921307
p_ni:  0.000078693
Score:  0.997
Data Source:  BioPlex,STRINGDB
FAM122B
Tdark
Novelty:  1.90668674
p_int:  0.999915216
p_ni:  0.000080099
p_wrong:  0.000004684
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.9999095
p_ni:  0.000090239
p_wrong:  2.6e-7
Data Source:  BioPlex
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.999829166
p_ni:  0.000169571
p_wrong:  0.000001263
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.99974142
p_ni:  0.000258297
p_wrong:  2.84e-7
Data Source:  BioPlex
STXBP2
Tbio
Novelty:  0.01896992
p_int:  0.999538132
p_ni:  0.000461866
p_wrong:  2e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
LIN54
Tbio
Novelty:  0.06173892
p_int:  0.999447359
p_ni:  0.00055162
p_wrong:  0.000001021
Score:  0.419
Data Source:  BioPlex,STRINGDB
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.999361562
p_ni:  0.000638435
p_wrong:  3e-9
Data Source:  BioPlex
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.999297329
p_ni:  0.000702671
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.998895547
p_ni:  0.000674716
p_wrong:  0.000429737
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
Miscellaneous transport and binding events
Reactome
Post-translational protein modification
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
Miscellaneous transport and binding events
Post-translational protein modification
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
40.7
forced expiratory volume
1
1
1
14.2
body height
1
1
1
14.2
FEV/FEC ratio
1
1
1
14.2
mathematical ability
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
40.7
forced expiratory volume
1
14.2
body height
1
14.2
FEV/FEC ratio
1
14.2
mathematical ability
1
3.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tumor suppressor candidate 3
701123
Mouse
MGI:1933134
80286
Rat
RGD:1303318
290783
Dog
tumor suppressor candidate 3
475608
Cow
tumor suppressor candidate 3
615007
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tumor suppressor candidate 3
Mouse
Rat
Dog
tumor suppressor candidate 3
Cow
tumor suppressor candidate 3
Publication Statistics
PubMed Score 86.67
PubMed score by year
PubTator Score 73.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title