You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TUSC2
Tumor suppressor candidate 2

Protein Summary
Description
May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells. This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232496
  • ENSP00000232496
  • ENSG00000114383

Symbol
  • C3orf11
  • FUS1
  • LGCC
  • PDAP2
  • PAP
  • FUS1
  • PDAP2
  • C3orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
disease perturbation
0.79
phenotype
0.79
cell type or tissue
0.77
biological process
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.24   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.24   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
HSPA4
Tbio
Novelty:  0.00009122
p_int:  0.998480738
p_ni:  0.001519262
Data Source:  BioPlex
PCP4
Tbio
Novelty:  0.00940968
p_int:  0.989932089
p_ni:  0.003971903
p_wrong:  0.006096008
Data Source:  BioPlex
HSPH1
Tbio
Novelty:  0.01617555
p_int:  0.98738472
p_ni:  0.01261528
Data Source:  BioPlex
HSPA4L
Tbio
Novelty:  0.05591399
p_int:  0.983669254
p_ni:  0.016330746
Data Source:  BioPlex
NMT2
Tchem
Family:  Enzyme
Novelty:  0.04826835
p_int:  0.965252519
p_ni:  0.034747469
p_wrong:  1.2e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.926327215
p_ni:  0.072570588
p_wrong:  0.001102197
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.853766349
p_ni:  0.146233651
Data Source:  BioPlex
HSPA2
Tchem
Novelty:  0.01696667
p_int:  0.847587259
p_ni:  0.152412741
Data Source:  BioPlex
NMT1
Tchem
Family:  Enzyme
Novelty:  0.00343834
p_int:  0.787026369
p_ni:  0.212973631
Score:  0.282
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
5
11
91.6
reticulocyte count
2
4
8
91
chronotype measurement
1
2
0
1
85.7
schizophrenia
4
2
0
1.1
83.3
mean reticulocyte volume
1
1
1
75.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
11
91.6
reticulocyte count
8
91
chronotype measurement
0
1
85.7
schizophrenia
0
1.1
83.3
mean reticulocyte volume
1
75.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1931086
80385
Rat
RGD:1561664
501052
Dog
tumor suppressor candidate 2
608576
Horse
tumor suppressor candidate 2 [Source:HGNC Symbol;Acc:HGNC:17034]
Cow
tumor suppressor 2, mitochondrial calcium regulator
VGNC:53155
100848754
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
tumor suppressor candidate 2
Horse
tumor suppressor candidate 2 [Source:HGNC Symbol;Acc:HGNC:17034]
Cow
tumor suppressor 2, mitochondrial calcium regulator
Publication Statistics
PubMed Score 33.24
PubMed score by year
PubTator Score 20.85
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title