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Tbio
TUSC1
Tumor suppressor candidate gene 1 protein

Protein Summary
Description
This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358022
  • ENSP00000350716
  • ENSG00000198680

Symbol
  • TSG9
  • TSG-9
  • CCDC89B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
tissue sample
0.63
virus perturbation
0.59
tissue
0.57
cellular component
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.28   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.28   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
EIF3D
Tbio
Novelty:  0.0360717
p_int:  0.999868893
p_ni:  4e-8
p_wrong:  0.000131067
Data Source:  BioPlex
GGPS1
Tchem
Family:  Enzyme
Novelty:  0.00292258
p_int:  0.996405899
p_ni:  6.4e-8
p_wrong:  0.003594037
Score:  0.513
Data Source:  BioPlex,STRINGDB
BNC2
Tbio
Family:  TF
Novelty:  0.0181682
Score:  0.688
Data Source:  STRINGDB
GXYLT2
Tdark
Family:  Enzyme
Novelty:  0.43960075
Score:  0.681
Data Source:  STRINGDB
ARAP2
Tbio
Novelty:  0.04566051
Score:  0.641
Data Source:  STRINGDB
SHQ1
Tbio
Novelty:  0.09779957
Score:  0.638
Data Source:  STRINGDB
LRRC19
Tbio
Novelty:  0.24840554
Score:  0.631
Data Source:  STRINGDB
FNDC4
Tbio
Novelty:  0.31597146
Score:  0.592
Data Source:  STRINGDB
RSU1
Tbio
Novelty:  0.01645054
Score:  0.588
Data Source:  STRINGDB
COPS8
Tbio
Novelty:  0.0408885
Score:  0.579
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
feeling emotionally hurt measurement
1
1
0
5.7
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
feeling emotionally hurt measurement
0
5.7
1.4
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor suppressor candidate 1
743395
Mouse
MGI:2684283
69136
Cow
tumor suppressor candidate 1
539580
Pig
tumor suppressor candidate 1 [Source:HGNC Symbol;Acc:HGNC:31010]
Opossum
tumor suppressor candidate 1 [Source:HGNC Symbol;Acc:HGNC:31010]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor suppressor candidate 1
Mouse
Cow
tumor suppressor candidate 1
Pig
tumor suppressor candidate 1 [Source:HGNC Symbol;Acc:HGNC:31010]
Opossum
tumor suppressor candidate 1 [Source:HGNC Symbol;Acc:HGNC:31010]
Publication Statistics
PubMed Score 9.28
PubMed score by year
PubTator Score 5.73
PubTator score by year
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Related Publications
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PMID
Year
Title