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Tbio
TULP4
Tubby-related protein 4

Protein Summary
Description
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367094
  • ENSP00000356061
  • ENSG00000130338
  • ENST00000367097
  • ENSP00000356064

Symbol
  • KIAA1397
  • TUBL4
  • TUSP
  • TUSP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
protein domain
0.92
transcription factor perturbation
0.88
microRNA
0.79
PubMedID
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.924
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999999978
p_ni:  2.1e-8
Score:  0.9
Data Source:  BioPlex,STRINGDB
DTX4
Tbio
Family:  Enzyme
Novelty:  0.11896749
p_int:  0.986333454
p_ni:  0.000341812
p_wrong:  0.013324734
Data Source:  BioPlex
CAND1
Tbio
Novelty:  0.0196525
Score:  0.92
Data Source:  STRINGDB
CISH
Tbio
Novelty:  0.00145893
Score:  0.912
Data Source:  STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.908
Data Source:  STRINGDB
LMO7
Tbio
Novelty:  0.03508141
Score:  0.905
Data Source:  STRINGDB
GPS1
Tbio
Novelty:  0.01433636
Score:  0.905
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.903
Data Source:  STRINGDB
SOCS5
Tbio
Novelty:  0.01181731
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
76.2
heel bone mineral density
2
2
2
71.1
smoking status measurement
2
2
2
65.7
platelet crit
1
1
1
46.9
leukocyte count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
76.2
heel bone mineral density
2
71.1
smoking status measurement
2
65.7
platelet crit
1
46.9
leukocyte count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubby like protein 4
VGNC:3777
472173
Mouse
MGI:1916092
68842
Rat
RGD:1564487
499016
Dog
tubby like protein 4
VGNC:47999
484053
Cow
tubby like protein 4
VGNC:36522
100294795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubby like protein 4
Mouse
Rat
Dog
tubby like protein 4
Cow
tubby like protein 4
Publication Statistics
PubMed Score 16.64
PubMed score by year
PubTator Score 5.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title