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Tdark
TULP2
Tubby-related protein 2

Protein Summary
Description
TULP2 is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. Members of this family have been identified in plants, vertebrates, and invertebrates. The TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221399
  • ENSP00000221399
  • ENSG00000104804

Symbol
  • TUBL2
  • CT65
  • TUBL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.63
protein domain
0.58
PubMedID
0.51
tissue
0.5
tissue sample
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
CTR9
Tbio
Family:  Enzyme
Novelty:  0.04434964
p_int:  0.999846657
p_ni:  0.000153343
Score:  0.151
Data Source:  BioPlex,STRINGDB
HDAC6
Tclin
Family:  Epigenetic
Novelty:  0.00122232
p_int:  0.998182874
p_ni:  0.001793295
p_wrong:  0.000023831
Score:  0.159
Data Source:  BioPlex,STRINGDB
PAF1
Tbio
Family:  Enzyme
Novelty:  0.00200047
p_int:  0.99772453
p_ni:  0.00227547
Score:  0.556
Data Source:  BioPlex,STRINGDB
LEO1
Tbio
Family:  Enzyme
Novelty:  0.00851903
p_int:  0.995765129
p_ni:  0.000105212
p_wrong:  0.004129659
Score:  0.741
Data Source:  BioPlex,STRINGDB
ZSWIM8
Tdark
Novelty:  0.26740136
p_int:  0.993289376
p_ni:  0.00651579
p_wrong:  0.000194834
Score:  0.183
Data Source:  BioPlex,STRINGDB
MAPK8IP2
Tbio
Family:  Enzyme
Novelty:  0.01788453
p_int:  0.992631546
p_ni:  0.00004728
p_wrong:  0.007321173
Score:  0.16
Data Source:  BioPlex,STRINGDB
IFT122
Tbio
Novelty:  0.02235986
p_int:  0.992551495
p_ni:  0.007448505
Score:  0.734
Data Source:  BioPlex,STRINGDB
WDR19
Tbio
Novelty:  0.037197
p_int:  0.990605743
p_ni:  0.009394248
p_wrong:  9e-9
Score:  0.446
Data Source:  BioPlex,STRINGDB
SIK2
Tchem
Family:  Kinase
Novelty:  0.01957886
p_int:  0.986704071
p_ni:  0.012925832
p_wrong:  0.000370097
Score:  0.177
Data Source:  BioPlex,STRINGDB
IFT140
Tbio
Novelty:  0.02872897
p_int:  0.983099007
p_ni:  0.016900921
p_wrong:  7.3e-8
Score:  0.581
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
5
6
96.1
red blood cell distribution width
4
3
5
95.1
reticulocyte count
6
4
12
94.4
eosinophil count
3
1
3
70.9
mean corpuscular hemoglobin concentration
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
6
96.1
red blood cell distribution width
5
95.1
reticulocyte count
12
94.4
eosinophil count
3
70.9
mean corpuscular hemoglobin concentration
1
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubby like protein 2
VGNC:2211
456192
Mouse
MGI:1861600
56734
Rat
RGD:1310551
361576
Dog
tubby like protein 2
VGNC:47997
484392
Horse
tubby like protein 2
VGNC:24667
100051453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubby like protein 2
Mouse
Rat
Dog
tubby like protein 2
Horse
tubby like protein 2
Publication Statistics
PubMed Score 4.17
PubMed score by year
PubTator Score 1.16
PubTator score by year
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Related Publications
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PMID
Year
Title