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Tchem
TUFM
Elongation factor Tu, mitochondrial

Protein Summary
Description
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313511
  • ENSP00000322439
  • ENSG00000178952

Symbol
  • P43
  • EFTU
  • COXPD4
  • EF-TuMT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
co-expressed gene
0.99
kinase perturbation
0.98
molecular function
0.96
histone modification site profile
0.94


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.82   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.82   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (442)
ZMYM6
Tdark
Novelty:  0.4933879
p_int:  0.997946499
p_ni:  0.002053501
Data Source:  BioPlex
GFM2
Tbio
Novelty:  0.02945848
p_int:  0.99578213
p_ni:  0.004210935
p_wrong:  0.000006936
Score:  0.566
Data Source:  BioPlex,STRINGDB
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.990030355
p_ni:  0.009969645
Score:  0.583
Data Source:  BioPlex,STRINGDB
MCCC1
Tbio
Family:  Enzyme
Novelty:  0.01234441
p_int:  0.984581967
p_ni:  0.015418033
Score:  0.374
Data Source:  BioPlex,STRINGDB
GAB1
Tchem
Novelty:  0.02174353
p_int:  0.978812982
p_ni:  0.021187011
p_wrong:  7e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.918795169
p_ni:  0.081204831
Data Source:  BioPlex
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.916375549
p_ni:  0.083624451
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.910955822
p_ni:  0.089044178
Data Source:  BioPlex
PUS1
Tbio
Family:  Enzyme
Novelty:  0.01923618
p_int:  0.882282853
p_ni:  0.117717135
p_wrong:  1.2e-8
Score:  0.718
Data Source:  BioPlex,STRINGDB
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.838942149
p_ni:  0.161057851
Score:  0.201
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Translation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
17
8
30
3.6
98.6
intelligence
8
12
5
6.8
94.1
cognitive function measurement
3
3
4
92.2
mathematical ability
3
2
3
91.4
grip strength measurement
2
2
2
88.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
30
3.6
98.6
intelligence
5
6.8
94.1
cognitive function measurement
4
92.2
mathematical ability
3
91.4
grip strength measurement
2
88.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Tu translation elongation factor, mitochondrial
VGNC:10132
454018
Macaque
Tu translation elongation factor, mitochondrial
705462
Rat
RGD:1305501
293481
Dog
Tu translation elongation factor, mitochondrial
VGNC:54083
479796
Horse
Tu translation elongation factor, mitochondrial
VGNC:24665
100064341
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Tu translation elongation factor, mitochondrial
Macaque
Tu translation elongation factor, mitochondrial
Rat
Dog
Tu translation elongation factor, mitochondrial
Horse
Tu translation elongation factor, mitochondrial
Publication Statistics
PubMed Score 35.82
PubMed score by year
PubTator Score 236.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title