You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TUBGCP4
Gamma-tubulin complex component 4

Protein Summary
Description
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260383
  • ENSP00000260383
  • ENSG00000137822
  • ENST00000564079
  • ENSP00000456648

Symbol
  • 76P
  • GCP4
  • 76P
  • GCP4
  • GCP-4
  • Grip76
  • MCCRP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
histone modification site profile
0.92
transcription factor perturbation
0.91
interacting protein
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
TUBG2
Tbio
Novelty:  0.14828466
p_int:  0.999992732
p_ni:  0.000007261
p_wrong:  7e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
TUBGCP5
Tbio
Novelty:  0.04863776
p_int:  0.999991653
p_ni:  0.000008175
p_wrong:  1.72e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MZT2B
Tdark
Novelty:  0.69469786
p_int:  0.999979095
p_ni:  0.000020585
p_wrong:  3.2e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
TXNDC12
Tbio
Novelty:  0.01354011
p_int:  0.999948013
p_ni:  0.000051987
Score:  0.736
Data Source:  BioPlex,STRINGDB
MZT1
Tdark
Novelty:  0.06713659
p_int:  0.999903982
p_ni:  0.000095682
p_wrong:  3.35e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
p_int:  0.999801541
p_ni:  0.000198459
Score:  0.188
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.99693663
p_ni:  0.003063364
p_wrong:  6e-9
Data Source:  BioPlex
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.995950546
p_ni:  0.004049352
p_wrong:  1.02e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.991621852
p_ni:  0.008375861
p_wrong:  0.000002287
Data Source:  BioPlex
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.975701301
p_ni:  0.024289659
p_wrong:  0.00000904
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Reactome
G2/M Transition
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
G2/M Transition
M Phase
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
2
8
93
hemoglobin measurement
2
2
2
92.9
triglyceride measurement
5
2
8
92.2
hematocrit
2
2
2
91.3
apolipoprotein A 1 measurement
1
1
1
81.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
8
93
hemoglobin measurement
2
92.9
triglyceride measurement
8
92.2
hematocrit
2
91.3
apolipoprotein A 1 measurement
1
81.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin gamma complex associated protein 4
VGNC:6457
453379
Macaque
tubulin gamma complex associated protein 4
710327
Mouse
MGI:1196293
51885
Rat
RGD:1306924
362203
Dog
tubulin gamma complex associated protein 4
VGNC:47994
100856688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin gamma complex associated protein 4
Macaque
tubulin gamma complex associated protein 4
Mouse
Rat
Dog
tubulin gamma complex associated protein 4
Publication Statistics
PubMed Score 17.77
PubMed score by year
PubTator Score 7.93
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title