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Tbio
TUBG2
Tubulin gamma-2 chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251412
  • ENSP00000251412
  • ENSG00000037042
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.91
histone modification site profile
0.66
interacting protein
0.66
protein complex
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.88   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.88   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
TUBGCP5
Tbio
Novelty:  0.04863776
p_int:  1
Score:  0.989
Data Source:  BioPlex,STRINGDB
MZT2A
Tdark
Novelty:  1.66535264
p_int:  0.99999982
p_ni:  7.9e-8
p_wrong:  1.01e-7
Score:  0.978
Data Source:  BioPlex,STRINGDB
TUBGCP4
Tbio
Novelty:  0.04549455
p_int:  0.999992732
p_ni:  0.000007261
p_wrong:  7e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
TUBGCP6
Tbio
Novelty:  0.05801955
p_int:  0.999991044
p_ni:  0.000008952
p_wrong:  4e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
TUBG1
Tbio
Novelty:  0.02252882
p_int:  0.99998397
p_ni:  0.00001603
Score:  0.97
Data Source:  BioPlex,Reactome,STRINGDB
TUBGCP3
Tbio
Novelty:  0.0221126
p_int:  0.999859712
p_ni:  0.000140288
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
MZT2B
Tdark
Novelty:  0.69469786
p_int:  0.999741843
p_ni:  0.000258154
p_wrong:  2e-9
Score:  0.981
Data Source:  BioPlex,STRINGDB
TUBGCP2
Tbio
Novelty:  0.01856674
p_int:  0.997566344
p_ni:  0.002433656
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
NME7
Tbio
Family:  Enzyme
Novelty:  0.08546782
p_int:  0.994137613
p_ni:  0.005862387
Score:  0.956
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.963579483
p_ni:  0.036420517
Score:  0.551
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Reactome
G2/M Transition
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
G2/M Transition
M Phase
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
4
4
80.5
BMI-adjusted waist-hip ratio
2
4
4
73.7
sex hormone-binding globulin measurement
2
1
2
70.8
4
3
1
1.1
68.8
testosterone measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
4
80.5
BMI-adjusted waist-hip ratio
4
73.7
sex hormone-binding globulin measurement
2
70.8
1
1.1
68.8
testosterone measurement
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin gamma 2
VGNC:9754
100611990
Horse
tubulin gamma 2
VGNC:24660
100052528
Cow
tubulin, gamma 2
540216
C. elegans
176361
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin gamma 2
Horse
tubulin gamma 2
Cow
tubulin, gamma 2
C. elegans
Publication Statistics
PubMed Score 5.88
PubMed score by year
PubTator Score 2.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title